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FOCIS 2022 Program
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Allergy
Th7 - Vitamin D Modulates Th2 Response by Mediating T Regulatory Cells in Allergic Conjunctivitis
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Th10 - Effect of Cigarette Smoke on Immune Response to Pollen Allergen in the Lung
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Th51 - High Compliance of Oral Immunotherapy and Improvement of Health-related Quality of Life in a Long-term Follow-up for Food Allergy Study
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Th59 - Investigating the Immune Basis of Green Tea Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01
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Th84 - Leveraging the OASIS Resource to Query LEAP GWAS Results in an Unbiased or Targeted Fashion
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Th104 - GPCR19 Agonist (HY209) Regulates P2X7 Ion Channel-mediated NLRP3 Inflammasomal Activation and Ameliorates Atopic Dermatitis in Mice
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Autoimmune Diseases
W3 - Anti-CD45RC Antibody Immunotherapy Prevents and Treats Experimental Autoimmune Poly Endocrinopathy Candidiasis Ectodermal Dystrophy Syndrome
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W8 - The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBV EBNA1 and GlialCAM
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Tu6 - Identification of Novel DRB1*01:01-restricted T Cell Epitopes in Rheumatoid Arthritis
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Tu9 - IL-6 Targeted Therapies Directed to Cytokine or Cytokine Receptor Blockade Drive Distinct Alterations in T Cell Function.
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W10 - Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis
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W21 - Reemergence of Pathogenic B Cell Clones in Autoimmune Myasthenia Gravis Tollowing B Cell Depletion Therapy
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W22 - Kv1.3−/− Mice Do Not Develop CIA: A Novel Target with Small Molecules for Autoimmune Arthritis
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W30 - Underlying T Cell Receptor Methylation Defects in Type 1 Diabetes Associated with Quantitative Defects
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W32 - Therapeutic Effects of Anti-IFNg Therapy in a Spontaneous Mouse Model of Myositis
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W36 - Plasma Levels of the MiR-193b/365a Cluster in Combination with Clinical Parameters Predict Response to Lactococcus Lactis-based Antigen-specific Combination Therapy
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W37 - JAK Inhibition in a Patient with a STAT1 Gain-of-function Variant Reveals STAT1 Dysregulation as a Common Feature of Aplastic Anemia
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W38 - Antigen-driven Ocular Immune Responses Distinguish Granulomatous and Non-granulomatous Uveitis
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W43 - Combined Germline and Somatic FADD Mutations as a New Cause of Autoimmune Lymphoproliferative Syndrome
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W47 - Immunometabolism Effect of Follicular Helper T Cells in Systemic Lupus Erythematosus
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W50 - A Dysregulated CXCR3+CCR6+ Adaptive Immune Rheostat Exists in Patients with Active Enthesitis-related Arthritis
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W59 - Deep Biology Approach for Development of Novel Therapeutics for Autoimmunity and Inflammation
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W64 - Association of rs763361 C>T and rs727088 G>A SNPs of DNAM-1 with CRP Levels and BASDAI Index in Ankylosing Spondylitis Patients
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W67 - Novel Therapy with Neddylation Inhibitor Delays the Progression of Disease in Pre-Diabetic Non-Obese Diabetic Mice by Restoring Endogenous Treg Function
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Th37 - Clonally Expanded CD8 T Cells Are Recruited to the CSF in Neurosarcoidosis Through the Chemokine Receptors CXCR3 and CXCR4
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Th45 - Autoreactive CD8+ T Cells are Restrained by an Exhaustion-like Program that is Maintained by LAG3
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Th49 - Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus
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Th52 - Childhood Idiopathic Nephrotic Syndrome is Characterized by Antigen-Experienced B-Cell Responses and Diminished Immunoregulation that are Differentially Targeted by Distinct Immunosuppressive Treatments
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Th69 - Oral Mucosal Breaks Trigger Unique Systemic Immune Responses that Mediate Rheumatoid Arthritis
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Th74 - Ex vivo Fold Expansion of Human Regulatory T Cells Negatively Correlates with Preservation of Beta Cell Function in Adolescent T1D subjects
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Th75 - Reduced CD8 T Cell Exhaustion in DR4 Risk Subjects is Selectively Augmented with Abatacept in RA
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Th89 - Increased Intrathecal Activity of Follicular Helper T Cells in Patients with Relapsing-Remitting Multiple Sclerosis
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Th97 - Utilization of a Clinical Data Research Network to Improve Identification of Systemic Lupus International Collaborating Clinics Classification Criteria Attributes in Patients with Systemic Lupus Erythematosus
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Th99 - Multi-omic Profiling in Celiac Disease Reveals Somatic Driver Mutations in Rogue T Cell Clones
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Tu11 - High-Dimensional Immunophenotyping Reveals Altered Regulatory T Cell Fitness Between Inactive and Active Disease in Juvenile Idiopathic Arthritis
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Tu12 - An In Silico Analysis to Predict the Function of Genes Associated with Type 1 Diabetes, Systemic Lupus Erythematosus, and Juvenile Idiopathic Arthritis in Colombian Patients
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Tu14 - Functional and Molecular Characterization of Th2 Cell Subsets in Type 1 Diabetes
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Tu18 - Targeted PD-1 Agonists as localized Immune Suppressants against Skin Autoimmune and Inflammatory Diseases
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Tu19 - Multi-parametric Interrogation of the Systemic Lupus Erythematosus (SLE) Immunome Reveals Multiple Derangements
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Tu41 - KIR+CD8+ T Cells Target Pathogenic T Cells and are Active in Autoimmune Diseases and COVID-19
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Tu42 - JAK Inhibitor Ruxolitinib Prevents Autoimmune Diabetes in Non-Obese Diabetes Mice through Inhibition of the JAK-STAT Pathway in Multiple Cell Types
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Tu43 - NaCl Exposure Results in Increased Expression and Processing of IL-1β in Meniere's Disease Patients
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Tu48 - Naïve Arthritogenic SKG T Cells have a Defect in Anergy and a Repertoire Pruned by Superantigen
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Tu62 - Impaired TIGIT Expression on B Cells Drives Circulating Tfh Cell Expansion in Multiple Sclerosis
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Tu77 - Selective CD226 Knockout on Regulatory T Cells Reduces Diabetes in Female Non-obese Diabetic Mice
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Tu79 - Searching for Environmental Triggers of Juvenile Dermatomyositis Using Antibody Profiling Technology
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Tu91 - Evaluation of Indirect Immunofluorescent Assays for LGI1 Antibody Detection in Patients with Anti-LGI1 Encephalitis
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W164 - Aging and Autoimmunity: Down Syndrome Gives a Master Class
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W173 - Rosnilimab, a Novel PD-1 Agonist Monoclonal Antibody, Demonstrated Modulation of Peripheral T Cell Activity and Reduction of Circulating PD-1high Expressing CD4 and CD8 T Cells in a Phase 1 Healthy Volunteer Clinical Trial
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Th171 - Gain of Function Mutation in SKAP2 Leading to Autoimmune Diabetes
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Th177 - Understanding the T Cell Repertoire in Autoimmune Diseases Using High-dimensional Single-cell Analysis of Antigen-specific CD4+ and CD8+ T Cells
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Th183 - Two Sources of Autoreactive T Cells in Patients with FOXP3 Mutations
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Tu100 - A Pathogenic Th17/CD38+ Macrophage Feedback Loop Drives Inflammatory Arthritis Through TNFa
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Tu106 - Phenotype-based Isolation of Antigen-specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease
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Tu107 - Increased Monocyte Activity in Patients with Primary Progressive Multiple Sclerosis
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Tu109 - SQZ® TAC Cell Therapy Platform Induces Antigen Specific T-regs and Prevents Onset of Type 1 Diabetes in Adoptive Transfer Models
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Tu110 - Understanding Neuro-Immune Interactions in Multiple Sclerosis Brain by Single Nucleus Profiling
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Tu123 - IL-23 Signaling Induces Autoimmune Disease Genes in Mucosal-associated Invariant T (MAIT) Cells
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Tu130 - Central Nervous System-specific Chimeric Antigen Receptor Regulatory T Cells for the Therapy of Multiple Sclerosis
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Tu132 - Induction of Antigen-Specific Immune Tolerance in Type 1 Diabetes by Antigen-Expressing Red Cell Therapeutics
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Tu133 - Mass Cytometry Demonstrates an Extrafollicular T and B cell Signature that Correlates with Disease Activity in Pediatric Lupus Nephritis
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Tu134 - High CD96 Expression Marks an IL-22 Producing CD4 T cell Population Reduced in Lupus Patients
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Tu136 - Intravenous Ofatumumab Treatment of Multiple Sclerosis and Related Disorders: An Observational Study
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Tu145 - STAT3 Gain-of-function Variants and T Cell-mediated Inflammation
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Tu149 - Plasma from Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) Induces Increased BBB Permeability Through Disruption of Tight Junction Proteins
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Tu150 - Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy
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Tu151 - GAD65 Mediated Inflammatory Immune Response In HLA-DR3/DQ2+ Type 1 Diabetes Patients
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Tu152 - Senescence Associated DNA Damage in Lymph Node and Synovial Tissue Biopsies of Early Rheumatoid Arthritis Patients
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Basic Science of Immunology - Adaptive Immunity
W5 - Human Aging, Autoimmunity, and Palmitate: The Fatty Acid Palmitate Induces Human B Cell Metabolic Reprograming and Autoimmunity in Aging and Obesity
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W24 - Interferon Gamma Induction of TH1-like Tregs Dampens Anti-viral Responses
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W39 - Identification of a Transcription Factor Network that Regulates Anti-TNF Mediated IL-10 Expression by Human CD4+ T-Cells
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W44 - An Automated Approach to High-Content Cytometric Immune Profiling of Human PBMC and Blood Samples
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W58 - Transcriptomic Comparison of Pediatric Acute Myeloid Leukemia Cells Sensitive or Resistant to Engineered Tr1-like Cell Mediated Killing
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W61 - Expression of TNFR2 and CD29 Define a Highly Suppressive Subset of Human CD8+ T Regulatory Cells
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W81 - Mass Cytometry to Define Healthy Immunotypes
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W88 - IL-21 is a Key Regulator of Chronic Germinal Centers in Autoimmune Settings
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Th40 - Profound abnormalities in thymic epithelial cells in Rag1 mutant mice: implications for immune reconstitution after stem cell transplantation
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Th77 - Postnatal Depletion of Maternal Cells Shifts Splenic NK and CD8+ T Cell Profiles Toward Mature and Activated Phenotypes
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W103 - IRF5 Regulation of CD4+ T Cell Metabolism Controls CD40L Expression
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W122 - Developing Trajectories of Immunosenescence in Diverse Adults
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W155 - Integrating Spatial Transcriptomics and Single-Cell RNA Sequencing to Spatially Characterize Human Lymphatic Tissue
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Th108 - T Cell Cross Reactivity Between Viral and Self-peptides in the Coronary Atherosclerotic Plaque
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Th115 - Barcode Enabled Antigen Mapping (BEAM) Enables Next-Generation Systems Immunology Analysis of the Post-COVID-19 Immune Landscape
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Th122 - Mutation of a Single Critical Region in the IgV of Butyrophilin 3 Reveals That One Chain Functions as a Sensor and the Other as a Ligand for the Sensing of Prenyl Pyrophosphates by Vγ2Vδ2 T Cells: Implications for Cancer Immunotherapy
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Basic Science of Immunology - Innate Immunity
W1 - Aryl Hydrocarbon Receptor Activity is Required Downstream IL-10 Signaling to Promote Regulatory Functions in Human Dendritic Cells
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W23 - Sex Differences in NK Cells Mediated by the X-linked Epigenetic Regulator UTX
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W28 - A SLIT3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
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W69 - Effect of Chronic Exposure to Abrocitinib on Immune Homeostasis in Mice
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W93 - Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics is Mediated by cIAP-2 and RIPK-1/3 Through the Activation of mTORC
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Tu35 - Single-cell Transcriptomic Analysis of Peripheral Blood Reveals the Disparate Subsets of Innate Immune Cells in Kidney Transplant Recipient with BK Virus Infection
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Tu45 - Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome of Macrophages via β-hydroxybutyrate and Fibroblast Growth Factor 21 in Humans
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Tu49 - Multi-OMICs Analysis of Metabolites, Proteins, and Histone Modifications During Human Macrophage Polarization Reveals Novel Regulatory Pathways
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Tu51 - Pim1 Positively Regulates Interferon Production by Interacting with IRF3
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Tu84 - Diverse Functional Profiles of Individual Human Gamma Delta T and iNKT Cells Revealed With a 32 Color Intracellular Cytokine Staining Spectral Flow Cytometry Panel
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Tu92 - TLR-4 Agonist Induces IFN-gamma Production Selectively in Pro-inflammatory Human M1 Macrophages Through the PI3K-mTOR and JNK-MAPK Activated p70S6K Pathway
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W150 - Natural Killer Cells may be Functionally Altered due to Simulated Microgravity Exposure
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W170 - TMEM176B is a Target to Control Pathogenic Inflammasome Activation in Obesity
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COVID-19
Tu5 - Serum IL-6 and PTX3 Predict Severe Outcome from Covid-19 in Ambulatory Subjects
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W65 - Longitudinal Dynamics of SARS-CoV-2 Specific Cellular Immunity to Different Vaccination Schemes
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W70 - SARS-CoV-2 Rapid Antigen Kit Efficacy in Comparison with Quant Studio 12 PCR Poster
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W71 - SARS-CoV-2 Neutralizing Antibody Presence in Infected and Vaccinated Patients
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W75 - A 10-Month Period Evaluation of Cellular Responses After ChAdOx1-nCoV-19 and BNT162b2 Vaccinations
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W87 - A Versatile New Monoclonal Antibody for Elucidating Human TMPRSS2 Expression and Function
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W90 - CSF Inflammatory and Neuroaxonal Damage Biomarkers in COVID-19 Associated Encephalopathy and Encephalitis
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Tu15 - Elevated anti-PEG Antibody Levels Amongst Covid-19 Vaccinated Donors
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Tu21 - Monitoring of Naturally Acquired and Vaccine-induced SARS-CoV-2 Specific Cellular Immune Responses
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Tu36 - SARS-CoV-2-specific T Cells in Unexposed Adults Display Broad Trafficking Potential and Cross-react with Commensal Antigens
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Tu38 - CLEC5A and TLR2 are Critical in SARS-CoV-2-induced Immunothrombosis and Lung Inflammation
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Tu40 - Humoral Response to Heterologous Prime-boost Vaccination with CoronaVac and BNT162b2 in Healthy Individuals and Solid Organ Transplant Recipients
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Tu46 - Quantitative Analysis of SARS-CoV-2 Antibody Titer After the 3rd Dose of COVID-19 Vaccination
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Tu53 - Rapid Waning and Unique Response Kinetics of Humoral and Cellular Immune Responses to SARS-CoV-2 Vaccination in Patients on Immunomodulatory Drugs
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Tu56 - Analysis of Antigen-Specific Cellular and Humoral Immune Response in COVID-19 Patients
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Tu96 - Epitope Profiling of COVID-19 Convalescent Plasma and Vaccine Elicited Antibodies
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W112 - B Cell Subsets as Severity-associated Signatures in COVID-19 Patients
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W125 - SARS-CoV-2 Antibody Kinetics in Healthcare Workers in Northern Metropolitan Barcelona
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W175 - Immunological Profiles of HIV-infected and Uninfected Patients Admitted with COVID-19 in Tshwane
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W185 - Fc Structure and Function of Antibodies Elicited by COVID-19 mRNA Vaccine and Infection
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Tu111 - Severity of SARS-CoV-2 Infection is Linked to Double Negative (CD27- IgD-) B Cell Subsets Numbers
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Tu126 - Efficacy and Safety of mRNA SARS-CoV-2 Vaccination in Hematopoietic Stem Cell Transplant Recipients: Single Centre Experience
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Tu137 - Allogenic and Autologous Stem Cell Transplant (SCT) Recipients have Detectable Levels of SARS-CoV-2 Antigen-specific T Cells One Month After mRNA Vaccination
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Tu138 - Sequence Similarity Between SARS-CoV-2 Nucleocapsid and CNS Proteins Provides Mechanistic Insight into Viral Neuropathogenesis Following Infection
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Tu158 - TNFα-producing CD4+ T Cells Dominate the SARS-CoV-2-specific T Cell Response in COVID-19 Outpatients and are Associated with Durable Antibodies
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Tu228 - Comprehensive assessment of SARS-CoV-2 antibodies after COVID-19 infection and vaccination (BNT162b2 or ChAdOx1 nCoV-19) using multiplex bead assay
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Immuno-engineering and Cellular Therapies
W4 - Tolerogenic Dendritic Cells Engineered with a Lentiviral Vector Encoding for IL-10 and Antigen Control T Cell Responses to Pathogenic Antigens
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Th1 - Clinical Grade CD8+T Regulatory Cells Moving Forward in Human Transplantation
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W11 - Combination of ImmTOR Tolerogenic Nanoparticles and IL-2 Mutein Induces Massive Expansion of Antigen-specific Regulatory T Cells
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W19 - MHC-deficient CD8+ Tregs as Universally Compatible Cell Therapy
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W62 - Osteosarcoma Tumorigenesis is Affected by Macrophage Behavior in 3D Engineered Bone Marrow Model
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W68 - Human CD4+CD25+ Regulatory T Cells Deficient of CD226 Demonstrate Increased Purity and Lineage Stability Following Ex Vivo Expansion for Adoptive Treg Therapies
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Th26 - CRISPR-Mediated Deletion of PD1 to Enhance the Efficacy of Human CAR Tregs
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Th33 - Developing Islet Antigen-Specific Regulatory T Cell For Therapy in Type 1 Diabetes
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Th39 - The Role of Chimeric Antigen Receptor (CAR) Versus Endogenous Co-stimulation in the Function of Alloantigen-specific Tregs
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Th50 - Elucidating Inflammation-induced Cell Fate Decisions in Primary Human Tregs
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Th61 - The Tolerogenic Effects of IL-2 on T Regulatory Cells (Tregs) are TGF-β Dependent
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Tu71 - Synthekines: A Novel Platform for Combinatorial Engineering of Cytokine Receptor Agonists
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Tu76 - A Robust, Xeno- and Feeder-Free Culture System for Expansion of Human Peripheral Blood NK Cells
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Tu80 - Discovery of T Cell Receptors for Adoptive T Cell Therapy Against Solid Tumors
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W118 - Ex vivo Production Of Immunotherapeutic NK Cells From Cord Blood Or Mobilized Peripheral Blood CD34+ Cells Using Notch Ligand Delta-Like 4 Culture System
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W119 - Neurofilament Light Chain Levels as a Potential Biomarker of Immune effector Cell-Associated Neurotoxicity Syndrome (ICANS) in Patients Treated with CAR T Cell Therapy
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W121 - Modulating Innate Immune Signaling with Nanomaterials to Drive Antigen-Specific Tolerance
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W157 - Segregating the Regional Effects of Aging and Blood Immune Factors on Age Related Brain Athrophy
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Th127 - Engineered Single Amino Acid Substitutions Protect Therapeutic Cells From CD123 Targeted Immunotherapy in vitro
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Th139 - Engineering Optimized Autoreactive T Cells for the Study of Type 1 Diabetes Pathogenesis
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Th140 - CAR-T Cells Mediated B Cell Depletion in EAE-induced Disease
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Th146 - Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses than Alternative Alloantigen-Specific Treg Strategies
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Tu105 - A Screening Platform for Drug Effects on Vaccine Responses Using Human Tonsil Immune Organoids
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Tu108 - Immunogenicity Induced by Full Academic CD19 Chimeric Antigen Receptor (ARI0001) in Patients Recruited into the CART-BE-01 Clinical Trial
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Tu117 - Deep Molecular Comparison Between Lymphoid Progenitor Cells Differentiated from CB or mPB CD34+ Hematopoietic Stem Cells Cultivated on Notch Ligand DLL4 Through a Clinically Compatible Culture Procedure
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Tu229 - Two-dimensional Materials for Biomedical Applications: MXenes Immune Profiling
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Immunogenetics
W63 - DiSiR: A Software Framework to Identify Ligand-receptor Interactions at Subunit Level from Single-cell RNA-sequencing Data
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W66 - Association of CTLA-4 (AT)n Genetic Variants in Basal Cell Carcinoma and Squamous Cell Carcinoma in Patients from Western Mexico
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W78 - Autoimmunity Risk Loci Tagged to CIITA and MHC Class II Impact CD8+ T Cell and Monocyte HLA-DR Expression
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W79 - A Hypermorphic Variant in CARD11 Leads to A Novel Inflammatory and Immune Regulation Disorder
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Tu57 - Genotype-Phenotype Correlation of T cell Subtypes Reveals Senescent and Cytotoxic Genes in Alzheimer’s Disease
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Tu59 - Multicohort Meta-Analysis of Bronchial Epithelial Cells Classifies Asthma from Healthy Subjects and Identifies Pathways in Asthma
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Tu98 - Development of a Classification Criteria-based Polygenic Risk Score for Systemic Lupus Erythematosus
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W131 - Altered Innate and Adaptive Immune Landscape in Pediatric Patients with Glycogen Storage Disease 1b
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W161 - Genome-wide Prioritization of Autoimmune Disease-associated Genetic Variants in T Cells Identifies a Risk Variant that Elicits Effector T Cell Differentiation
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W167 - CRISPR-based Functional Genomics in Primary Human T Cell Subsets Decode Cis and Trans Regulation of the CD28, CTLA4, and ICOS Costimulatory Locus
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Tu114 - Prediction of HLA Genotypes from Single-cell Transcriptome Data
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Tu156 - A GATA3 Frameshift Mutation Alters DNA-binding Causing Loss of Th2 Polarization in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome
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Immuno-oncology
W9 - Glucose Metabolism Controls Human γδ-T Cell-mediated Tumor Immunosurveillance in Diabetes Through AMPK Pathway
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Th6 - A CXCR4/PLC-mediated Cell Survival Pathway is Involved in Steroid Resistance of B-acute Lymphoblastic Leukemia
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W17 - Immune Remodelling in Advanced Adenocarcinoma by a CD40L-MUC1 Vaccine
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W56 - Evaluation of GPER Activation Pathways Associated with Migration and Invasion in LNCaP Cells
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W74 - The Tumor Suppressor APC Regulates T Lymphocytes Migration: Insights from Familial Polyposis Patients
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Th20 - An Academic BCMA-directed CAR-T Therapy (ARI0002h) with Fractionated and Booster Dose in Patients with Relapsed/Refractory Multiple Myeloma: First Data About Efficacy and Safety
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Th32 - A Case of μ Heavy and λ Light Chain Amyloidosis in a Patient with Bi-clonal (IgM κ and λ ) Gammopathy Successfully Treated with Daratumumab
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Th34 - Performance Comparison of the Spectral Signature, Spillover Spreading Matrix, and Data Unmixing Quality Between the Spectral Cytek Aurora and the Spectral BD FACS Symphony A5 SE by a 35-Color Human Broad Immunophenotyping Panel
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Th42 - Next-generation Immunostimulatory Antibody-drug Conjugate (iADC) Combines Direct Tumor Killing and Innate Immune Stimulation to Provide Protective Anti-Tumor Immunity
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Th47 - Single Cell and Spatially Resolved Analysis of Tissues by Integrated RNA and Protein Multi-omics Identifies Novel Tumour-infiltrating Lymphocyte Phenotypes
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Th72 - Engineering of Alpha/Beta Selective IL-2 Muteins for Antigen Activated T cells in Solid Tumors
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Th80 - The Role of Mucosal-Associated Invariant T (MAIT) Cells in Glioblastoma Immunity
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Tu52 - NKG2D Co-stimulation Differentially Reprograms CD8 T Cells for Enhanced Memory Formation and Homeostasis in Mouse Prostate Tumors
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Tu74 - CD3+CD56+ Cells in Cervical Cancer Patients: Evaluation of Immune Checkpoint Expression
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Tu81 - Multiplexed Single-cell Analysis Reveals Dysfunctional CD8+ CD103+ T Cells and Negatively Prognostic CD38+ Regulatory T Cells in Human Colorectal Cancer
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Tu83 - Anti-TIGIT Antibodies Promote Immune Activation in Combination with Immunotherapeutic Agents
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Tu86 - Rescuing Antitumor Responses Mediated by Immune Checkpoint Inhibition Through Jak Inhibition
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Th111 - Metastatic melanoma (MM) patients with stable disease display reduced Mo-MDSCs levels in peripheral blood
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Th142 - Evaluation of the MAPK and PI3K Signaling Pathways in Cancer Stem Cells Isolated from Prostate Cancer Tumor Tissues, a Preliminary Study
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Th165 - Induction of a T Cell Intrinsic DNA Damage and Repair Response is Associated with Clinical Response to PD-1 Blockade
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Th178 - The CDKN2A Deletion Influences the Establishment of the Tumor Immune Microenvironment of Pancreatic Ductal Adenocarcinoma
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Tu120 - Spatial Whole Transcriptome Profiling of the Tumor Microenvironment in FFPE Prostate Carcinoma using the Visium Platform
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Tu128 - Enhanced Function of Vaccine Dendritic Cells from Obese Donor upon Inhibition of Lipid Metabolism
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Tu141 - Correlation of GPER with GLI1 and GLI3 in Tumor and Stromal Tissue with Different Prognosis Groups of Patients with Prostate Cancer
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Tu147 - Regulatory T Cell Functional Dynamics During The Response To PD-1 Blockade
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Tu153 - Comprehensive Analysis of the Immune Landscape in the Peripheral Blood of Advanced Melanoma Patients Reveals Chronic Activation of Differentiated Cytolytic Cell Subsets
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Infectious Diseases
W26 - Serum Levels of IgG Antibodies Against Oxidized LDL and Atherogenic Indices in HIV-1-infected Patients Treated with Protease Inhibitors
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W94 - Herpes Simplex Virus Type 1 Modulation of Neutral Lipid Metabolism in Dendritic Cells Affects the Function of These Cells
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W95 - Targeting Cholesterol Metabolism as a Novel Immune Checkpoint in Viral Infections and Cancer
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Th46 - Calibrating T Cell ‘Help’ by Antigen Cross-linking as a Universal Vaccine Platform Against Rapidly Evolving Pathogenic Viruses
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W113 - Identification of Conserved Detrimental Host Immune Response Predicts Severity of Bacterial and Viral Infections
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W179 - Platelet Activation Through TRPC6 Mediates Cystic Fibrosis Lung Inflammation and Injury
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W184 - CGC+ CD4+ T Cells are Cytomegalovirus Specific Cells that are Biomarkers of Cardiometabolic Disease Risk in Persons with HIV
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Th135 - Biomarkers of Disease Outcome in Lassa Fever
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Th154 - Diminished Vδ2+ γδ T cell Cytokine Production and Degranulation Following in vitro Malaria Exposure
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Th159 - A Nine-Gene Blood-Based Signature Meets the World Health Organization (WHO) Target Product Profiles for Diagnosis of Active Tuberculosis and Predicting Progression from Latent to Active Disease
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Th182 - High-Throughput B Cell Epitope Determination by Next-Generation Sequencing
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Inflammatory Diseases
W2 - Conventional and Unconventional T-Cell Sources of IL-17A and IL-17F in Psoriatic Arthritis
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W13 - Vedolizumab Reduces Dendritic Cells and Naïve Lymphocytes in the Colon Mucosa
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W35 - Exaggerated Inflammatory Response During Acute Lung Injury: Role of Mitochondrial ROS and NLRP3 Inflammasome
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W49 - Brain-homing Monocytes Identified in Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are Immunosuppressive
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Th38 - A Novel Ultrasensitive Assay Enables Measurement of IL-11 in Fibrosing Disease Patients and Healthy Donor Samples
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Th41 - The Therapeutic Potential of Hematopoietic Stem Cell IL-1RA Gene Therapy for the Treatment of Hereditary IL-1-mediated Autoinflammatory Syndromes
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Th54 - Pre-existing Cardiothoracic Comorbidity and Lung Disease in Still's
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Th55 - Impaired T Cell Mitochondrial Function and Metabolic Shifts in Glycolysis Characterize Axial Spondylarthritis
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Th62 - Bioengineering Probiotic Yeast to Secrete Anti-Proinflammatory Cytokine Antibodies for Resolving Gut Inflammation
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Th63 - Non-Conventional CD8+IL-13+ T Cells in Refractory Atopic Dermatitis Patients
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Th76 - The Effect of TRPV1+ Neuron-derived Neuropeptides on Cytokine Production of Th1 and Th17 Cells
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W143 - Dynamic Peripheral Immune Proteins in Extremely Premature Infants
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W166 - Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome can cause Secondary Hemophagocytic Lymphohistiocytosis with a Unique Immune and Genetic Profile
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Th163 - The Minor Allele of a Single Nucleotide Polymorphism in SH2B3 Promotes CD8+ T Cell IFNg Production, Hypertension Development, and Renal Damage
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Mucosal Immunology
Th19 - Regulation of Antigen Presenting Cells by Retinal Pigment Epithelial Cells
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Th25 - IL-33 and IL-4 Synergize to Dysregulate TREG Cell Function and Promote Type 2 Responses in RSV-induced Asthma
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Th30 - Use of Ex Vivo Lung Perfusion to Study the Immune Response to Influenza Viral Challenge in Human Lung
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Th60 - High Salivary IgA-coating Levels of the Oral Microbiota in Patients with Systemic Lupus Erythematosus (SLE)
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Th144 - Single Cell Analysis Reveals Altered Regulatory T Cells in Neonates with Necrotizing Enterocolitis
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Th162 - Commensal Myeloid Crosstalk in Neonatal Skin Regulates Long-term Cutaneous Type 17 Inflammation
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Th181 - AMT-126: A Novel Oral GI-selective Fusion Protein Delivering IL-22 to Support Mucosal Homeostasis and Epithelial Barrier Integrity
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Stem Cell and Organ Transplantation
Th5 - Spatial Whole Transcriptome Analysis of Human Kidney Histological Structures using Digital Spatial Profiling
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Tu4 - Molecular Signature of Myeloid Cells during Ischemia-Reperfusion Injury in Human Liver Transplantation
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W60 - Racial and Ethnic Disparities in Detection of Donor-Specific HLA Antibodies
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Th14 - Crosstalk Between Alloimmunity and Ischemia-Reperfusion Injury in Human Liver Transplantation
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Th16 - Effects of Cytomegalovirus on T Cell Differentiation in Two Distinct Immunosuppressed Populations
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Th18 - Long Term Expanded Purified Allospecific Tr1 Cells Maintain a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines and Express a Chemokine Receptor Profile Involved in Allograft Tolerance.
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Th56 - A Novel Multiplex Digital PCR Method Offering Rapid Quantitation of Donor and Recipient DNA After Transplantation
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Th64 - Renal Allograft Rejection: New Paradigms in T Cell Reactivity Revealed by Single Cell RNAseq Analysis
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Th73 - Pilot Study of a Novel Anti-CD5 Antibody-drug Conjugate for Combined Peripheral and Thymic Lymphocyte Depletion in a Cynomolgus Macaque Model
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Tu20 - Chimerism and Bidirectional Alloresponses in Patients Receiving Lung Transplantation
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Tu31 - Development of Proliferating Cell Nuclear Antigen Autoantibodies with Manifestation of Graft Versus Host Disease after Peripheral Blood Stem Cell Transplantation
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Tu44 - Immunotherapy Using IL-34 for the Treatment of GvHD and Solid Organ Rejection: Strategies for its Optimisation
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Tu82 - Detecting Alloreactive T Cells in Transplant Recipients with a Trogocytosis Assay
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Tu85 - Long-term Impact of Atopy in Kidney Transplantation
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Th168 - Differentiation of Human iPSc into Functional Thymic Organoids for in vitro T Cell Generation and Cell Therapy
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Th169 - Detection and Clonal Dynamics of Alloreactive T Cells in a Kidney Transplant Recipient Experiencing Acute Rejection After Immune Checkpoint Inhibitor Therapy
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Tu101 - A Novel Organotypic Model of Skin Rejection
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Tu116 - Bac Transgenic Overexpression Mice Recapitulate the Immunologic Role of Exonic Variants of APOL1
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