Senior Scientist Trex Bio San Francisco, California, United States
Abstract Text: Tissue-specific immune processes control treatment outcomes in cancer and inflammation. We developed a deep understanding of human tissue Tregs behavior to enable a next generation of therapeutics aimed at activating or disarming these regulatory circuits at the location where the disease manifests. Single-cell RNA sequencing and computational tools are used on various healthy and multiple inflammatory diseases, focusing on barrier tissues to generate a high-resolution map of immune-regulatory pathways that prioritize pathways and targets. This in silico and multi-dimension functional interrogation of tissue Treg pathways allowed us to identify novel regulatory nodes and forms the foundation of our growing pipeline of a new class of tissue Treg focused therapeutics for autoimmune and inflammatory diseases. We will present data of how this approach enabled us to identify novel drug targets to alter biological Treg regulatory functions to promote productive immunity.
