Category: Diabetes
Poster Session III
We examined whether racial and ethnic differences exist in the associations between pregnancy dysglycemia and cardiometabolic outcomes 10 to 14 years’ postpartum.
Study Design: Pregnant individuals in the HAPO Follow-up Study enrolled in the U.S. were included. The exposure was maternal dysglycemia, defined by a summary z-score incorporating the fasting, 1-, and 2-hour values of a 75-gram oral glucose tolerance test at 24-32 weeks. Study outcomes 10-14 years’ postpartum were type 2 diabetes/prediabetes, hypertension, dyslipidemia, and obesity. Effect modification between each self-reported race and ethnicity subgroup (non-Hispanic Black and Hispanic compared to non-Hispanic White as the reference) and summary z-score were evaluated using interaction terms. If interactions were statistically significant (p < 0.05), analyses were stratified by race and ethnicity in order to gain insight into potential consequences of social determinants of health upon cardiometabolic health.
Results:
Among 1,012 assessed individuals, 11% (n=107) identified as Black, 48.7% (n=493) as Hispanic, and 40.7% (n=412) as White. Black and Hispanic individuals were significantly more likely to have a higher frequency of cardiometabolic risk factors compared to White individuals at enrollment and 10-14 years’ postpartum (Table 1). A higher glycemia z-score was associated with a similarly increased risk of prediabetes/diabetes and total cholesterol for all individuals (interaction p-value >0.05) (Table 2). Higher glycemia z-scores were associated with increased risk of hypertension among White individuals, but not among Black and Hispanic individuals (interaction p-value 0.03 and 0.02, respectively). Glycemia z-scores were not associated with the risk of obesity, LDL cholesterol, HDL cholesterol, and triglycerides for assessed racial and ethnic subgroups.
Conclusion:
Associations between pregnancy dysglycemia and subsequent cardiometabolic outcomes 10 to 14 years postpartum largely were similar regardless of racial and ethnic identity for individuals enrolled at U.S. sites in the HAPO Follow-up Study.
Kartik Kailas Venkatesh, MD, PhD (he/him/his)
Assistant Professor
The Ohio State University
Columbus, Ohio, United States
Sadiya S. Khan, MD, MSc
Assistant Professor of Medicine
Northwestern University Feinberg School of Medicine
Oak Park, IL, United States
Jiquiang Wu, MSc
The Ohio State University
Columbus, Ohio, United States
Patrick Catalano, MD
Professor
Tufts Medical Center, Mother Infant Research Institute
Boston, Massachusetts, United States
Mark B. Landon, MD
Richard L. Meiling Professor and Chair, Obstetrics and Gynecology
The Ohio State University
Columbus, Ohio, United States
Denise Sholtens, PhD
Northwestern University
Chicago, Illinois, United States
William Lowe, MD
Northwestern University
Chicago, Illinois, United States
William A. Grobman, MD, MBA
Vice Chair, Clinical Operations, Maternal Fetal Medicine
The Ohio State University
Columbus, Ohio, United States