Category: Ultrasound/Imaging
Poster Session III
To assess the influence of intra-amniotic infection and/or inflammation (IAI) on fetal corpus callosum.
Study Design:
Prospective cohort study (2018-2021) conducted in Hospital Clinic and Hospital Sant Joan de Déu (BCNatal, Barcelona) including singleton pregnancies.
The exposed group included women with preterm labor (PTL) and/or preterm prelabor rupture of membranes (PPROM) with IAI (positive amniotic fluid culture and/or high levels of IL6) (group A) and without IAI (group B). The non-exposed group included women without PTL/PPROM (group C).
Corpus callosum were assessed by neurosonography calculating the total area (mm2) and Witelson subdivisions (WS) areas (mm2) in the first 72h from admission and, in non-exposed women, at a similar gestational age. Data were adjusted for EFW up to 10th centile, fetal sex and head circumference.
Results:
For the overall population, 41 had IAI (28/41 were PPROM), 54 had symptoms of PTL/PPROM without IAI (6/54 were PPROM), and 48 were non-exposed women (without symptoms of PTL/PPROM). There were no significant differences in maternal characteristics (including maternal age, BMI, ethnicity, smoking habit, prevalence of hypertension, pregestational diabetes or artificial reproduction techniques and parity), fetal sex, head circumference, or gestational age at ultrasound between groups. There were more fetuses with estimated fetal weight under 10th centile in the IAI group.
Fetuses with IAI or with PTL/PPROM without IAI presented smaller corpus callosum total area when compared to non-exposed group. Witelson subdivisions 3, 5 and 6 were those with smaller areas in these groups.
Conclusion: Fetuses with PTL or PPROM had smaller corpus callosum when compared with controls, suggesting changes in prenatal brain development of fetuses at risk of preterm delivery.
Teresa Cobo, MD, PhD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Teresa Cobo, MD, PhD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Clara Murillo, MD (she/her/hers)
Hospital Clinic Barcelona - BCNatal
Barcelona, Catalonia, Spain, Spain
David Boada, MD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Marta Larroya, MD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Elena Monterde, MD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Claudia Rueda, MD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Silvia Ferrero, MD, PhD
Hospital Sant Joan de Deu - BCNatal
Barcelona, Catalonia, Spain, Spain
Laia Grau, MD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain
Elisenda Eixarch, MD, PhD
BCNatal
Barcelona, Catalonia, Spain, Spain
Montse Palacio, MD, PhD
Hospital Clinic Barcelona-BCNatal
Barcelona, Spain, Spain