Category: Infectious Diseases
Poster Session IV
A retrospective cohort of pregnant subjects was obtained from the de-identified Cerner Real-World Database from January 2020 to March 2022. Pregnant subjects who had at least one COVID-19 vaccine dose and infection thereafter were included. The primary variable of interest was the time interval between the first documented vaccination and the first positive test. ANOVA was used to calculate significance (p < 0.05) between mean intervals.
Results: There were 389,764 pregnant people in the database during this time period. Of these, 44,846 were vaccinated and 407 had a subsequent positive COVID-19 test. Across all age groups, the average number of days between vaccination and breakthrough infection was 173.78 (SD ±107.14). Subjects in the 10-25 year-old and 46-55 year-old age groups had the shortest time intervals to breakthrough infection (149.53 and 149.4 days, respectively) (Table 1). There was no statistically significant difference in mean time to breakthrough infection between age groups (p=0.47). A higher percentage of breakthrough infections occurred after pregnancy in every age group except the 10-25 age group (Figure 1).
Conclusion: This is one of few studies evaluating breakthrough COVID-19 infection patterns in the pregnant population after vaccination. While there was no significant difference in interval periods between age groups, trends in the data suggest shorter intervals in the age extremes within the pregnant population. Future studies may look at the efficacy of different vaccine schedules during pregnancy in mitigating breakthrough infections.
Devon O'Brien, MD
Maternal-Fetal Medicine Fellow
University of Missouri-Kansas City
Kansas City, Missouri, United States
Julie Vircks, DO,MBA,FACOG (she/her/hers)
MFM Fellow
University of Missouri-Kansas City School of Medicine
Kansas City, Missouri, United States
Shruti Kumar, MD
University of Missouri-Kansas City
Kansas City, Missouri, United States
Yahia Mohamed, MBBCH, MS
University of Missouri-Kansas City
Kansas City, Missouri, United States
Imaima Casubhoy, BA (she/her/hers)
Medical Student
University of Missouri-Kansas City
Kansas City, MO, United States
David Mundy, MD
University of Missouri-Kansas City
Kansas City, Missouri, United States
Suman Sahil, MBA
University of Missouri-Kansas City
Kansas City, Missouri, United States
Devika Maulik, MD
MFM
University of Missouri Kansas City
Kansas City, Missouri, United States