Category: Genetics
Poster Session II
Retrospective study of nationwide inpatient sample (NIS) using ICD-9 codes from 2007-2013. Our analysis identified delivery admissions from women aged 10-60 years old with and without a diagnosis of fetal chromosomal abnormality (ICD-9-CM 655.1*). Severe maternal morbidity (SMM) was defined by the Centers for Disease Control and Prevention, and comorbidity index was defined by previously published criteria. HDP is defined as gestational hypertension, pre-eclampsia with and without severe features. Rates of SMM and HDD were compared between aneuploidy and non-aneuploidy pregnancies using Chi square analysis. National estimate was estimated using discharge weight index for each data point. Multivariate logistic regression was used to evaluate the association between fetal chromosomal abnormality and SMM and HDP while adjusting for previously validated maternal comorbidity index (high: >2, moderate: 1 and low: 0) and maternal age.
Results:
A total of 5,568,980 pregnancies without fetal chromosomal abnormality were compared to 4,259 pregnancies with fetal chromosomal abnormality. Pregnancies with fetal chromosomal abnormality had higher rates of SMM (2.03% vs 1.5%, p=0.004) and HDP (8.75% vs 7.46%, p=0.002). When adjusting for comorbidity index and age, rates of SMM were similar among groups (aOR 1.08, 95% CI 0.98-1.19, p=0.014). However, after adjusting for comorbidity index and age, pregnancies with fetal chromosomal abnormality had higher risk of HDP (aOR 1.18, 95% CI 1.06-1.32, p=0.002).
Conclusion: Fetal chromosomal aneuploidy is associated with increased risk of hypertensive disorders of pregnancy. Future research should focus implications of these findings in regions with limited access to reproductive choice.
Maeve Hopkins, MD
Associate Staff
Department of Maternal-Fetal Medicine, Obstetrics, Gynecology and Women’s Health Institute, Cleveland Clinic
Rocky River, Ohio, United States
Lauren Buckley, MD, MS (she/her/hers)
OB/GYN Resident
Obstetrics, Gynecology and Women’s Health Institute, Cleveland Clinic
Cleveland, Ohio, United States
Sarah K. Dotters-Katz, MD
Assistant Professor
Duke University Medical Center
Durham, North Carolina, United States
Manesha Putra, MD (he/him/his)
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States