Abstract: Market studies show a growing trend towards natural and clean ingredients in cosmetics, personal care products and insect repellent products. Consumers desire safe, effective alternatives for insect repellents that are N,N-diethyl-meta-toluamide (DEET) free. Although DEET is safe and effective when used as directed, there is a perception that it may be harmful if used above recommended levels and many consumers prefer to use natural or nature-identical ingredients for their family. Ethyl butylacetylaminopropionate more commonly known as IR3535® is classified by the EPA as a biopesticide. Biopesticides are considered as a reduced risk pesticide, they are naturally occurring substances or synthetically derived equivalents that have a non-toxic mode of action to the target pest(s). Biopesticides produce little or no toxic residue, tend to decompose quickly resulting in lower exposures and minimizing pollution concerns typical of conventional pesticides. This presentation will review recent dermatological testing on volunteers with sensitive, atopic skin, mosquito repellency and safety data that makes IR3535® suitable for use on adults and young children. IR3535® was also tested for repellency of lice, various species of flies, ticks, bees, and wasps with very favorable results. Cage and field test studies with Aedes aegypti, Ae. albopictus, Anopheles sp., Culex sp. show protection time between 8-12 h. IR3535® is shown to be nontoxic to aquatic organisms, non-persistent with no bioaccumulation in aquatic systems. Using sewage treatment simulation assay OECD 303A resulted in biodegradation at 99% with complete mineralization. The repellent is rapidly biodegradable in soils and not considered to be persistent or bioaccumulating. Studies show that IR3535® is rapidly biodegradable in sediment and not persistent or bioaccumulating in the sediment. Conclusion; IR3535® is well suited to meet the growing concerns for sustainable development goals for human health and well-being, responsible consumption and production, concern for life on land and in the waters.
