OC 04 - TTP: New Mechanisms, Diagnosis and Treatment

Moderator(s)

• 

  Karen Vanhoorelbeke, PhD

  Prof., Dr.
  Chemistry
  Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium
  Kortrijk, West-Vlaanderen, Belgium
• 

  Kazuya SAKAI, MD, PhD

  Dr.
  Laboratory for Thrombosis Research
  Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk
  8500, West-Vlaanderen, Belgium

Presentations:

• 1:00 PM – 1:15 PM

  Management of thrombotic thrombocytopenic purpura (TTP) without plasma exchange: an update on the Austrian experience
  

  Presenting Author: Paul Knoebl, MD – Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Vienna, Austria

  Co-Author: Kathrin Eller – Division of Nephrology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria

  Co-Author: Veronika Buxhofer-Ausch – Department of Internal Medicine I with Hematology, Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinnen, Linz, Austria

  Co-Author: Johannes Thaler, MD, PhD – Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Austria

  Co-Author: Karoline Gleixner – Med.Univ.Vienna, Dept.Med. 1

  Co-Author: Wolfgang Sperr – Med.Univ.Vienna, Dept.Med.1
• 1:15 PM – 1:30 PM

  Factors influencing time from initial presentation to start of plasma exchange in patients with acute thrombotic thrombocytopenic purpura in the United Kingdom
  

  Co-Author: Tom Bull – West Suffolk NHS Foundation Trust, UK

  Co-Author: Rory McCulloch – Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK

  Presenting Author: Andrew J. Doyle, MBChB MRCP FRCPath – Guy's & St Thomas' NHS Foundation Trust

  Co-Author: Phillip LR Nicolson – University of Birmingham

  Co-Author: Robecca Shaw – Royal Liverpool Hospital

  Co-Author: Zara Sayar, MBChB MD MRCP FRCPath – University College London Hospitals NHS Foundation Trust, London, UK; Whittington Hospital, London, UK

  Co-Author: Alexander Langridge – Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK

  Co-Author: Michala Pettitt – Birmingham Centre for Observational and Prospective Studies, Birmingham Surgical Trials Consortium, Birmingham, UK

  Co-Author: Rita Perry – Birmingham Centre for Observational and Prospective Studies, Birmingham Surgical Trials Consortium, Birmingham, UK

  Co-Author: David Tucker – Royal Cornwall Hospitals NHS Trust, Truro, UK

  Co-Author: Marie Scully, MD – Department of Haematology, University College London Hospitals, London, UK
• 1:30 PM – 1:45 PM

  N-glycan-mediated shielding of ADAMTS13 effectively prevents binding of pathogenic autoantibodies in high-titer patients with immune-mediated Thrombotic Thrombocytopenic Purpura
  

  Presenting Author: Tim Postmus – Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Nuno Graca – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Bogac Ercig – Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands

  Co-Author: Brenda Luken – Sanquinnovate

  Co-Author: Paul Coppo – Service d’Hématologie, Hôpital Saint-Antoine, APHP.6-SU, INSERM UMRS 1138, Centre de Recherche des Cordeliers, Paris, France.

  Co-Author: Agnes Veyradier – Université Paris Diderot UFR Médecine

  Co-Author: Karen Vanhoorelbeke, PhD – Laboratory for Thrombosis Research, KU Leuven Campus Kulak, Kortrijk, Belgium

  Co-Author: Jan Voorberg – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
• 1:45 PM – 2:00 PM

  Disease Relapse in immune Thrombotic Thrombocytopenic Purpura and treatment with Anti-CD20 Monoclonal Antibodies – 10-years’ experience from the UK TTP Registry
  

  Presenting Author: Andrew J. Doyle, MBChB MRCP FRCPath – Guy's & St Thomas' NHS Foundation Trust

  Co-Author: Matthew Stubbs – University College Hospitals London NHS Foundation Trust

  Co-Author: Tina Dutt, PhD – Liverpool University Hospitals NHS Foundation Trust

  Co-Author: Will Lester – University Hospitals Birmingham NHS Foundation Trust

  Co-Author: Will Thomas, MD – Cambridge University Hospitals NHS Foundation Trust

  Co-Author: Joost Vanveen – Sheffield Teaching Hospitals NHS Trust

  Co-Author: Joannes Hermans – Nottingham University Hospitals NHS Trust

  Co-Author: Tanya Cranfield – Portsmouth Hospitals University NHS Trust

  Co-Author: Quentin Hill – The Leeds Teaching Hospitals NHS Trust

  Co-Author: Beverley J. Hunt, MD, FRCP, FRCPath – Guy's & St Thomas' NHS Foundation Trust

  Co-Author: Amanda Clark – University Hospitals Bristol NHS Foundation Trust

  Co-Author: Tim Nokes – University Hospital Plymouth NHS Trust

  Co-Author: Sylvia Benjamin – Oxford University Hospital NHS Foundation Trust

  Co-Author: Catherine N. N. Bagot, Dr MBBS MD – Department of Haematology, Glasgow Royal Infirmary, Glasgow, United Kingdom

  Co-Author: Nichola Cooper – Hammersmith Hospital

  Co-Author: Steven Austin – St George's University Hospital NHS Foundation Trust

  Co-Author: Mari Thomas, MD, PhD – University College Hospitals London NHS Foundation Trust

  Co-Author: John-Paul Westwood – University College Hospitals London NHS Foundation Trust

  Co-Author: Marie Scully – Bloomsbury Institute of Intensive Care Medicine
• 2:00 PM – 2:15 PM

  Immune Medicated Thrombotic Thrombocytopenic Purpura relapse is associated with HLA-DRB1*15:01
  

  Presenting Author: Matthew J. Stubbs, MBChB, PhD – University College London Hospitals NHS Foundation Trust

  Co-Author: Andrew J. Doyle, MBChB MRCP FRCPath – Guy's & St Thomas' NHS Foundation Trust

  Co-Author: Chris Cheshire – University College London

  Co-Author: Adam P. Levine – University College London

  Co-Author: Mari Thomas, MD, PhD – University College Hospitals London NHS Foundation Trust

  Co-Author: John-Paul Westwood – University College London Hospitals NHS Foundation Trust

  Co-Author: Robert Kleta – University College London

  Co-Author: Daniel P. Gale – University College London

  Co-Author: Horia Stanescu – University College London

  Co-Author: Marie Scully, MD – Department of Haematology, University College London Hospitals, London, UK