OC 07 - Coagulation Factor Biology

Moderator(s)

• 

  Rawya Al Rifai

  PhD candidat
  Institut für experimentelle Hämatologie und Transfusionsmedizin
  Uniklinikum Bonn
  bonn, Nordrhein-Westfalen, Germany
• 

  Aaron Fogelson, PhD

  Professor
  Mathematics
  University of Utah
  Salt Lake City, Utah, United States

Presentations:

• 1:00 PM – 1:15 PM

  Role of GABARAP protein in the intracellular distribution of FVIII
  

  Presenting Author: Salime El-Hazzouri – Uniklinikum Bonn

  Co-Author: Heike Singer – Uniklinikum Bonn

  Co-Author: Mira Ibrahim – Uniklinikum Bonn

  Co-Author: Nicole Nüsgen – Uniklinikum Bonn

  Co-Author: Johannes Oldenburg – Institute of Experimental Hematology and Transfusion Medicine and Centre for Rare Diseases, Universitätsklinikum Bonn

  Co-Author: Osman El-maarri – Uniklinikum Bonn
• 1:15 PM – 1:30 PM

  Macrophage Galactose Lectin (MGL) is a clearance receptor determining Factor VIII half-life in haemophilia A patients
  

  Co-Author: Soracha E. Ward, PhD – Royal College of Surgeons in Ireland

  Co-Author: Thomas Guest* – Royal College of Surgeons in Ireland

  Co-Author: Jamie M. O'Sullivan – Royal College of Surgeons in Ireland

  Co-Author: Alain Chion, PhD – Royal College of Surgeons in Ireland

  Co-Author: Judicael Fazavana – Royal College of Surgeons in Ireland

  Co-Author: Padraic G. Fallon – Trinity College Dublin

  Co-Author: Roger Preston – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI)

  Co-Author: Jill M. Johnsen, MD – University of Washington

  Co-Author: Steven W. Pipe, MD – Departments of Pediatrics and Pathology, University of Michigan

  Co-Author: Peter L. Turecek, PhD, PharmD – Baxalta Innovations GmbH, a Takeda company

  Presenting Author: James S. O'Donnell, MD, PhD – Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland (RCSI)
• 1:30 PM – 1:45 PM

  Whole genome expression analysis resolves the correlation between genetic knockout of single genes and the obtained phenotype in relation to FVIII secretion
  

  Presenting Author: Rawya Al Rifai – Uniklinikum Bonn

  Co-Author: Muhammad Ahmer Jamil – Uniklinikum Bonn

  Co-Author: Mira Ibrahim – Uniklinikum Bonn

  Co-Author: Nicole Nüsgen – Uniklinikum Bonn

  Co-Author: Heike Singer – Uniklinikum Bonn

  Co-Author: Johannes Oldenburg – Institute of Experimental Hematology and Transfusion Medicine and Centre for Rare Diseases, Universitätsklinikum Bonn

  Co-Author: Osman El-maarri – Uniklinikum Bonn
• 1:45 PM – 2:00 PM

  Exploring the conformational landscape of Factor VIII B domain in order to generate an all atom full length structure of the coagulation Factor VIII protein
  

  Presenting Author: Samhitha Urs Ramaraje Urs, MSc – Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn

  Co-Author: Sneha Singh, M.Sc, PhD – Uniklinikum Bonn

  Co-Author: Haroon Javed, MSc – Universitätsklinikum Bonn

  Co-Author: Daphna Fenel – Institut de Biologie Structurale, University Grenoble Alpes

  Co-Author: Jean Marie Teulon – Institut de Biologie Structurale, University Grenoble Alpes

  Co-Author: Guy Schoehn – Institut de Biologie Structurale, University Grenoble Alpes

  Co-Author: Jean Luc Pellequer – Institut de Biologie Structurale, University Grenoble Alpes

  Co-Author: Boxue Ma – Materials and Structural Analysis Division, Thermo Fisher Scientific, Achtseweg Noord

  Co-Author: Deniz Ugurlar – Materials and Structural Analysis Division, Thermo Fisher Scientific, Achtseweg Noord

  Co-Author: Diana Imhof – University of Bonn

  Co-Author: Johannes Oldenburg – Institute of Experimental Hematology and Transfusion Medicine and Centre for Rare Diseases, Universitätsklinikum Bonn

  Co-Author: Arijit Biswas, PD Dr (Biol) – Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn
• 2:00 PM – 2:15 PM

  Mathematical modeling to identify clotting factor combinations that enhance thrombin generation in hemophilia
  

  Co-Author: Michael T. Stobb – Coe College

  Co-Author: Karin Leiderman, PhD – Colorado School of Mines

  Co-Author: Suzanne Sindi – University of California Merced

  Presenting Author: Aaron Fogelson, PhD – University of Utah

  Co-Author: Keith Neeves, PhD – University of Colorado Denver

  Co-Author: Dougald M. Monroe, PhD – UNC Blood Research Center