OC 29 - Crosslinking and Fibrin Function

Moderator(s)

• 

  Verena Schroeder, PhD

  Research Group Leader, PI, Study Director for the Master in Pharmacy
  Department for BioMedical Research (DBMR)
  University of Bern
  Bern, Bern, Switzerland
• 

  Joanne Mitchell, PhD

  Postdoctoral Research Fellow
  ICVS
  University of Birmingham
  Birmingham, England, United Kingdom

Presentations:

• 2:45 PM – 3:00 PM

  Both α- and γ-chain crosslinks mediated by FXIIIa affect fibrin fibre resistance to rupture
  

  Presenting Author: Timea Feller, PhD – Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds.

  Co-Author: Cédric Duval, PhD – University of Leeds

  Co-Author: Simon D. Connell – Molecular and Nanoscale Physics Group, School of Physics, University of Leeds.

  Co-Author: Robert A.S Ariëns, PhD – Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom
• 3:00 PM – 3:15 PM

  Surface exposure of cellular factor XIII on activated platelets and platelet microparticles is unrelated to the elevation of cytoplasmic Ca2+ concentration
  

  Presenting Author: Laura Somodi – University of Debrecen

  Co-Author: Ildikó Beke Debreceni – University of Debrecen

  Co-Author: Gréta Kis – University of Debrecen

  Co-Author: Marco Cozzolino – University of Debrecen

  Co-Author: János Kappelmayer – University of Debrecen

  Co-Author: Miklós Antal – University of Debrecen

  Co-Author: György Panyi – University of Debrecen

  Co-Author: Helga Bárdos – University of Debrecen

  Co-Author: Nicola J. Mutch, PhD – University of Aberdeen

  Co-Author: László Muszbek – University of Debrecen, Medical Faculty, Department of Laboratory Medicine, Division of Clinical Laboratory Science,
• 3:15 PM – 3:30 PM

  Fibrinogen αC-Connector is Critical for Fibrin Fiber Assembly and Mechanical Strength
  

  Co-Author: Ali Daraei – UCLA

  Co-Author: Taylor Dement – East Carolina University

  Co-Author: Heather Belcher – East Carolina University

  Co-Author: Nathan Hudson – East Carolina University

  Presenting Author: Martin Guthold, PhD – Wake Forest University
• 3:30 PM – 3:45 PM

  Development of recombinant antibodies targeting the coagulation factor XIII-B subunit for research and therapeutic use
  

  Presenting Author: James R. Byrnes – University of California, San Francisco

  Co-Author: Colton Bracken – University of California, San Francisco

  Co-Author: James Wells – University of California, San Francisco
• 3:45 PM – 4:00 PM

  Dysregulated fibrinogen γ-chain cross-linking in FibγΔ5 mice drives acute liver injury after acetaminophen overdose
  

  Presenting Author: Lauren G. Poole, PhD – Michigan State University

  Co-Author: Dafna J. Groeneveld – Michigan State University

  Co-Author: Holly M. Cline-Fedewa – Michigan State University

  Co-Author: Matthew J. Flick, PhD – University of North Carolina at Chapel Hill

  Co-Author: James P. Luyendyk, PhD – Department of Pathobiology and Diagnostic Investigation, Michigan State University