PB0102 - Prevalence of cerebrovascular MRI markers in hospitalized patients with COVID-19

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: In-Person

Presenting Author(s)

Naomi T. Wijers, Msc, MD

MD, PhD Candidate
Leiden University Medical Centre department of Neurology, Leiden; The Netherlands
Leiden, Zuid-Holland, Netherlands

Co-Author(s)

Tv

Theresa J. van Lith

MD, PhD Candidate
Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands
Nijmegen, Gelderland, Netherlands
WS

Wouter M. Sluis

MD, PhD Candidate
Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
Utrecht, Utrecht, Netherlands
FM

Frederick Meijer

MD, PhD
Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands
Utrecht, Utrecht, Netherlands
KK

Karin Kamphuis-van Ulzen

MD
Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands
Nijmegen, Gelderland, Netherlands
Jd

Jeroen de Bresser

MD, PhD
Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Leiden, Zuid-Holland, Netherlands
JD

Jan Willem Dankbaar

MD, PhD
Department of Radiology and Nuclear Medicine, University Medical Center, Utrecht University, Utrecht, The Netherlands
Utrecht, Utrecht, Netherlands
Frederikus A. Klok, MD, PhD

MD, PhD
Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands
Leiden, Zuid-Holland, Netherlands
AT

Anil M. Tuladhar

Neurologist, MD, PhD
Department of Neurology, Center for Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Nijmegen, Gelderland, Netherlands
SC

Suzanne C. Cannegieter, MD PhD

Professor
Department of Clinical Epidemiology, Leiden University Medical Center
Leiden, Zuid-Holland, Netherlands
MW

Marieke Wermer, MD

Neurologist
Department of Neurology, Leiden University Medical Center Leiden; The Netherlands
Leiden, Zuid-Holland, Netherlands
Bv

Bart van der Worp

Neurologist
Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
Utrecht, Utrecht, Netherlands
MH

Menno V. Huisman

MD, PhD
Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands
Leiden, Zuid-Holland, Netherlands
Fd

Frank-Erik de Leeuw

Professor
Department of Neurology, Center for Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Nijmegen, Gelderland, Netherlands

Background: COVID-19 is complicated by symptomatic ischemic stroke in 1% to 3% in small selected studies of hospitalized patients.

Aims: We aimed to assess the prevalence of cerebrovascular MRI markers and its causes in large samples of unselected patients with COVID-19, compared to healthy controls, which is unknown.

Methods: CORONIS is an ongoing observational cohort study in adult hospitalized patients with COVID-19. Patients without clinically overt stroke undergo standardized questionnaires, cognitive assessment, blood sampling, cardiac echo, telemetry and brain MRI within 90 days after COVID-19 infection. Controls undergo standardized questionnaires and brain MRI. MRI markers include (acute) ischemic lesions, microbleeds, white matter hyperintensities, and intracranial vessel wall abnormalities and contrast enhancement. Brain MRI will be repeated after 3 months in a subset of patients. Cognitive function and functional outcome are assessed after 3 and 12 months after baseline measurements.

Results: This is an ongoing study with preliminary results. Between April and December 2021, we recruited 88 patients with a median age of 59 years (range 22-82), of whom 59 (67%) are men and 25 (28%) had been admitted to the ICU. DWI lesions were found in 1 patient (1%), microbleeds in 22 patients (23%) and white matter hyperintensities in 66 (75%). Intracranial vessel wall enhancement was seen in 16%. Control results will follow.

Conclusion(s): The CORONIS study will provide insight into the frequency and risk factors of MRI markers of cerebrovascular lesions and its relation with long-term functional outcome in hospitalized adult patients with COVID-19.