OC 36 - FV/TFPI/PS

Moderator(s)

• 

  Josefin Ahnström, PhD

  Senior Lecturer
  Immunology and Inflammation
  Imperial College London
  London, England, United Kingdom
• 

  Mettine Bos, PhD

  Assistant Professor
  Internal Medicine, Div. of Thrombosis and Hemostasis
  Leiden University Medical Center

Presentations:

• 10:45 AM – 11:00 AM

  The CLEC4M locus participates to the regulation of FV plasma levels: insights from a new genome-wide association study conducted in 4,373 participants
  

  Presenting Author: David-Alexandre TREGOUET, PhD (he/him/his) – Bordeaux Population Health research center - INSERM UMR1219

  Co-Author: Angel Martinez-Perez – Genomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau, IIB Sant Pau

  Co-Author: Marcus Kleber – Department of Medicine, University Heidelberg, Mannheim Medical Faculty

  Co-Author: Astrid van Hylckama Vlieg, PhD – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Marine Germain – University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219, Bordeaux, France.

  Co-Author: Jean-François Deleuze – Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH)

  Co-Author: Juan Carlos Souto – Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau and Intitut d’Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain.

  Co-Author: Nicholas L. Smith – Department of Epidemiology, School of Public Health, University of Washington

  Co-Author: Maria Sabater-Lleal – Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

  Co-Author: Graciela Delgado – V Medicine Clinic, University of Heidelberg

  Co-Author: Frits R. R. Rosendaal – Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Pierre-Emmanuel Morange, MD, PhD – Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, Hôpitaux de Marseille, Marseille, France
• 11:00 AM – 11:15 AM

  Hydrophobic patch (PLVIVG 1481-1486) in FV-Short crucial for its synergistic TFPI-cofactor activity with protein S and the formation of a FXa-inhibitory complex comprising FV-Short, protein S and TFPI
  

  Presenting Author: Bjorn Dahlback, MD, PhD – Lund University

  Co-Author: Sinh Tran – Lund University, Dept Translational Medicine
• 11:15 AM – 11:30 AM

  Analysis of TFPI-protein S anticoagulant function in vivo.
  

  Presenting Author: Anastasis Petri, MSc, PhD – Imperial College London

  Co-Author: Parvathy Sasikumar – Imperial College London

  Co-Author: Patricia Badia Folgado – Imperial College London

  Co-Author: David Jones – The Francis Crick Institute

  Co-Author: Josefin Ahnström, PhD – Imperial College London

  Co-Author: Isabelle I. Salles-Crawley, BSc, MSc, PhD – St George's University of London

  Co-Author: James TB Crawley – Imperial College London
• 11:30 AM – 11:45 AM

  A Tethered Artificial Protease Reveals the Location of Key Regulatory Motifs in Factor V
  

  Presenting Author: Francis Ayombil, PhD – Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia

  Co-Author: Raffaella Toso – Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia

  Co-Author: Rodney M. Camire – Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
• 11:45 AM – 12:00 PM

  The TFPIα C-terminal tail is essential for the synergistic enhancement of TFPIα mediated inhibition of FXa by protein S and FV-short.
  

  Presenting Author: Magdalena Gierula, PhD MSc – Imperial College

  Co-Author: Victoria M. Noakes – Imperial College London

  Co-Author: Isabelle I. Salles-Crawley, BSc, MSc, PhD – St George's University of London

  Co-Author: James TB Crawley – Imperial College London

  Co-Author: Josefin Ahnström, PhD – Imperial College London