Associate Professor
University of Washington, Washington, United States
Cole Trapnell is an Associate Professor of Genome Sciences at the University of Washington. His lab has developed or co-developed single-cell genomics assays and the algorithms needed to analyze them. The lab has used these technologies to dissect the genetic architecture that governs cell fate decisions in various settings, including development, reprogramming, and disease. The Trapnell lab has worked to broadly disseminate software and protocols to help the wider community overcome “rate-limiting” steps in molecular, developmental, and computational biology.
Cole Trapnell has formal training in both computational and experimental biology, with a broad background in functional genomics and specific training in next generation sequencing and gene expression analysis. As a graduate student with Steven Salzberg and Lior Pachter, Dr. Trapnell wrote TopHat and Cufflinks, two widely used tools for transcriptome sequencing (RNA-seq) analysis.
At the University of Washington, Dr. Trapnell's lab has developed or improved both computational and experimental techniques in single-cell genomics. The lab wrote and maintains “Monocle”, a widely used software package for single-cell RNA-seq analysis, and has used it to explore pancreatic islet development, olfactory neurogenesis, and thyroid hormone-dependent pigmentation. The lab also co-developed, along with Jay Shendure’s lab, a general, ultra-scalable workflow for single-cell genomics called “combinatorial cellular indexing”. The lab recently used this approach to construct a transcriptional atlas for the C. elegans nematode and profile organogenesis in the mouse at whole-embryo scale. Having generated gene expression profiles for millions of cells, the latter effort represents one of the largest single cell transcriptome analyses performed to date.
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Wednesday, February 9, 2022
10:30 AM – 11:00 AM