DNA-Encoded Libraries

Session Chair - Not Funded(s)

• 

  Christoph Dumelin, PhD

  Senior Principal Scientist
  Novartis, Zurich, Switzerland

This session will focus on the utility of DNA-encoded libraries for hit identification. Specific attention will be paid to strategies for selection including screening for functional activity, eliminating non-specific binders, and managing challenging targets such as DNA-binding proteins and membrane proteins. We will also look at employing ML/AI for data analysis, triaging hits to make off-DNA, and discuss challenges in elucidating the real hit from the chemical recipe and engage in discussions on library scale and diversity.

Presentations:

• 10:00 AM – 10:30 AM

  DNA-encoded library technology (DELT) as an efficient and versatile hit finding platform in lead discovery
  

  Micah Steffek, MS – Genentech
• 10:30 AM – 11:00 AM

  Recent developments in the selection methods for DNA-encoded chemical libraries
  

  Xiaoyu Li, PhD The University of Chicago; B.S. Peking University – The University of Hong Kong