Postdoctoral Associate Massachusetts Institute of Technology
This presentation will introduce a new in vitro model for subcutaneous delivery of monoclonal antibodies or other therapeutics. The model consists of a self-assembled and perfusable vasculature from dermal microvascular cells, co-cultured with human dermal fibroblasts and stem cell-derived adipocytes. A lymphatic system is also included, grown from human lymphatic endothelial cells. Measures of biodistribution include vascular permeability, lymphatic drainage rate, fraction bound to extracellular matrix and diffusion coefficient.
Learning Objectives:
- understand how microphysiological models might be useful in predicting bioavailability in vivo.
- explore ways in which in vitro models might be useful as an alternative to animal studies.
- see the future potential for moderate throughput screening methods to predict aspects of drug bioavailability.
