Spectradyne’s nCS1 system, based on Microfluidic Resistive Pulse Sensing (MRPS), measures the size and concentration of nanoparticles with superior resolution. The system is especially useful in applications requiring measurement of biological nanoparticles such as protein aggregates, lipid nanoparticles (LNPs), extracellular vesicles, virus, and others. An electrical detection method, MRPS maintains excellent sensitivity when measuring particles of high transparency, such as EVs. Using a microfluidic-based measurement cartridge requiring only 3µL of sample, the system overcomes the limitations found with light scattering-based methods, particularly with respect to resolving polydispersity, being material-independent and being able to accurately measure concentration.