Novel Insights into Gait, Motor Control, and the Brain: Implications for Cognitive Aging

Chair(s)

• AR

  Andrea Rosso, MPH,PhD

  Associate Professor
  Epidemiology
  University of Pittsburgh
  Pittsburgh, Pennsylvania, United States

  Slides

Discussant(s)

• RH

  Roee Holtzer, PhD

  Professor
  Psychology and Neurology
  Yeshiva University and Albert Einstein College of Medicine
  New York, New York, United States

Individual Symposium Abstract First Author(s)

• 

  Talia Salzman, MSc

  PhD candidate
  School of Human Kinetics
  University of Ottawa
  Ottawa, Ontario, Canada
• CR

  Caterina Rosano, MD, MPH

  Tenured Professor
  School of Public Health
  University of Pittsburgh
  Pittsburgh, Pennsylvania, United States
• 

  Emma Baillargeon, PT, DPT, PhD

  Postdoctoral Scholar
  School of Public Health
  University of Pittsburgh
  Pittsburgh, Pennsylvania, United States
• BS

  Briana Sprague, PhD

  School of Public Health
  University of Pittsburgh
  Pittsburgh, Pennsylvania, United States
• 

  Qu Tian, PhD, MS

  Associate Scientist
  Longitudinal Studies Section, Translational Gerontology Branch
  National Institutes on Aging
  Baltimore, Maryland, United States

What can muscles, gait, and brain activity tell us about cognitive decline? Are there certain markers we can track that are early predictors of cognitive status years later? In the current symposia, our goal is to address these questions with recent pilot, longitudinal and cross-sectional studies that measure potential markers of cognitive decline in different older adult cohorts. The first speaker will present findings on changes in skeletal muscle adiposity and 10-year change in global cognition from the Health Aging and Body Composition (Health ABC) study. The second speaker explores cross-national comparisons of gait speed and its association with cognitive function from the Cohort Studies of Memory in an International Consortium (COSMIC). The third speaker investigates changes in brain activity with functional near infra-red spectroscopy (fNIRS) from single to dual-task walking and its relation to changes in several gait quality parameters. The fourth speaker presents pilot work that examines dual-task gait and tapping with fNIRS and compares the dual-task performance and brain activity of older adults who report experiencing subjective cognitive decline to those that do not. The final speaker presents findings from the Baltimore Longitudinal Study on Aging (BLSA) that demonstrate that early markers of slow gait and metabolic dysfunction could identify those at risk of progression to dementia 7 years prior to onset. Taken together, the findings from this symposium present novel markers of changes in cognitive function in older adults and ultimately targets for prevention or slowing of cognitive declines in older adults at risk for dementia.

Presentations:

• 12:00 PM – 1:30 PM ET

  What Can Dual-Task Walking and Tapping Tell Us About Subjective Cognitive Decline? An fNIRS Study
  

  Individual Symposium Abstract First Author: Talia Salzman, MSc – University of Ottawa
• 12:00 PM – 1:30 PM ET

  Intermuscular Adiposity: A Novel Risk Factor for Cognitive Decline in a Biracial Cohort of Older Adults
  

  Individual Symposium Abstract First Author: Caterina Rosano, MD, MPH – University of Pittsburgh
• 12:00 PM – 1:30 PM ET

  Dual-Task Changes in Prefrontal Activation and Gait Quality in Older Adults
  

  Individual Symposium Abstract First Author: Emma M. Baillargeon, PT, DPT, PhD – University of Pittsburgh
• 12:00 PM – 1:30 PM ET

  Cognitive Correlates of Gait Speed Among Older Adults From Six Countries: Findings From the COSMIC Collaboration
  

  Individual Symposium Abstract First Author: Briana N. Sprague, PhD – University of Pittsburgh
• 12:00 PM – 1:30 PM ET

  Early Characteristics and Biomarkers of Cognitive Impairment and Dementia With Prior Motor Impairment
  

  Individual Symposium Abstract First Author: Qu Tian, PhD, MS – National Institutes on Aging