Senescence and Inflammation

Friday, November 4, 2022

10:00 AM – 11:30 AM ET

Location: 205 CC

CE: 1.5

Chair(s)

Marissa Schafer, PhD

Assistant Professor
Physiology and Biomedical Engineering Research
Mayo Clinic
Rochester, Minnesota, United States

Individual Symposium Abstract First Author(s)

Marissa Schafer, PhD

Assistant Professor
Physiology and Biomedical Engineering Research
Mayo Clinic
Rochester, Minnesota, United States
Birgit Schilling, PhD (she/her/hers)

Associate Professor
Schilling laboratory
Buck Institute for Research on Aging
Novato, California, United States
Matt Yousefzadeh, PhD

Research Assistant Professor
Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics
University of Minnesota
Minneapolis, Minnesota, United States
Daniel Tyrrell, PhD

Assistant Professor
Pathology
University of Alabama at Birmingham
Birmingham, Alabama, United States
Xu Zhang, PhD

Research Associate
Robert and Arlene Kogod Center on Aging
Mayo Clinic
Rochester, Minnesota, United States

Cell senescence and inflammation are interconnected mediators of aging and age-related disease. Recent advances in molecular and cellular profiling methods and research models are aiding in our ability to decipher mechanisms through which senescent cells drive inflammatory dysfunction, and inversely, to discover mechanisms through which aging immune cells may drive senescence, inflammation, and pathology. This symposium will feature exciting advances that span the emerging conceptual framework of how senescence and inflammation influence mammalian aging. Dr. Birgit Schilling will discuss the use of advanced mass spectrometric methods for profiling the senescent cell proteome, which reveal new insights into protein pathways and mechanisms of aging and disease. Dr. Matt Yousefzadeh will share how endogenous DNA damage can invoke cellular senescence, which enhances inflammation in both a cell autonomous and non-autonomous manner to drive tissue dysfunction and impact health. Dr. Daniel Tyrrell will discuss discovery of a novel population of age-associated CD8 T-cells that enhance local tissue senescence and inflammation and promote atherosclerosis. Dr. Xu Zhang will share a characterization of senescent cells in skeletal muscle using single-cell RNA-sequencing and the potential recruitment of immune cells by senescent fibroadipogenic progenitors. Dr. Marissa Schafer will discuss cell senescence as a mediator of age-related brain inflammatory cell composition and senescent cell targeting as a strategy to prevent cognitive decline. Importantly, discoveries discussed in this symposium may reveal new avenues for therapeutic development, to ultimately improve human healthspan.

Learning Objectives:

At the conclusion of this session, audience members should be able to describe how senescent cells can influence inflammatory activation in tissues and conversely, how aged immune cells can drive inflammation and senescence in aged tissues.
At the conclusion of this session, audience members may recognize that the senescence-associated secretory phenotype (SASP) of senescent cells is a mechanism by which senescent cells adversely influence tissue homeostasis.
At the conclusion of this session, audience members may recognize that senescent cell targeting is an important therapeutic opportunity for countering age-related conditions.

Presentations:

10:00 AM – 11:30 AM ET

Cell Senescence Is a Feature and Modulator of the Aged Inflammatory Brain Cell Landscape
Individual Symposium Abstract First Author: Marissa J. Schafer, PhD – Mayo Clinic
10:00 AM – 11:30 AM ET

Senescence-Derived Protein Biomarkers During Aging and Osteoarthritis
Individual Symposium Abstract First Author: Birgit Schilling, PhD (she/her/hers) – Buck Institute for Research on Aging
10:00 AM – 11:30 AM ET

Endogenous DNA Damage as a Driver of Aging and Tissue Dysfunction
Individual Symposium Abstract First Author: Matt Yousefzadeh, PhD – University of Minnesota
10:00 AM – 11:30 AM ET

Age-Associated Granzyme K-Expressing CD8+ T-Cells Enhance Atherosclerosis in Mice
Individual Symposium Abstract First Author: Daniel Tyrrell, PhD – University of Alabama at Birmingham
10:00 AM – 11:30 AM ET

Identification and Investigation of Senescent Cells in Skeletal Muscle Aging
Individual Symposium Abstract First Author: Xu Zhang, PhD – Mayo Clinic