Presenting Author
Tulane University School of Medicine
Name: Dewan Syed Abdul Majid, MD; PhD; FAHA; FASN; FAPS
Position title: Professor of Physiology
Institution: Tulane University School of Medicine, New Orleans. LA, USA
Personal Statement: As a faculty in the Department of Physiology, the research activities in my laboratory at Tulane (~32 years) are centered on to elucidate the regulatory mechanism of renal hemodynamics and excretory function by vasoactive substances produced by endothelial cells as well as the renal pathophysiologic mechanism of salt-sensitive hypertension. In this aspect, particular attention is given to determine the interactive roles for nitric oxide, reactive oxygen species, and inflammatory cytokines in the regulation of renal hemodynamics and excretory function. Over the last decade, the experimental efforts in my laboratory have been directed to understand the role of inflammatory cytokines, particularly tumor necrosis factor-alpha (TNFα) in the patho-physiology of salt-sensitive hypertension. While exploring the TNF’s role on renal function, it has been confirmed that the circulating TNFα exerts natriuresis via its action on TNFα receptor type 1 (TNFR1) in the kidney. In the present study, we examined the effects of changes in NaCl concentration in the media on TNFR1 expressions on cultured renal proximal (HK2) and cortical collective duct (M1) cells to understand how tubular sodium reabsorption is regulated by TNFR1 activity in renal tubules during changes in salt intake and salt sensitive conditions