367 - Evolution of Drug Resistance

Session Chair(s)

• Robert Gatenby

  Speaker
  Moffitt Cancer Center

This session will explore how cancers evolve resistance to therapies. It will explore the importance of tumor heterogeneity, both genetic and epigenetic, and the microenvironment in the evolution of drug resistance. Attendees will also learn about the tradeoffs associated with drug resistance, and how these costs can be exploited for the design of more effective and less toxic therapeutic regimen. The application of evolutionary approaches to understand and to treat cancers will be demonstrated for multiple malignancies, including breast and prostate cancers and multiple myeloma.

Presentations:

• 8:00 AM – 8:10 AM

  Introduction
  

  Speaker: James DeGregori – University of Colorado Anschutz Medical Campus
• 8:10 AM – 8:35 AM

  Exploiting Darwinian Dynamics to Delay or Prevent Evolution of Resistance in Treated Cancer Populations
  

  Speaker: Robert Gatenby – Moffitt Cancer Center
• 8:35 AM – 9:00 AM

  Evolutionary Dynamics of Disease Progression and Therapy Resistance in Multiple Myeloma
  

  Speaker: Ariosto Silva – Moffitt Cancer Center
• 9:00 AM – 9:25 AM

  Combating Evolutionary Drug Resistance by Targeting Heterogenous Cell-cell Interactions
  

  Speaker: Rena Emond – City of Hope
• 9:25 AM – 9:30 AM

  Conclusion