21 - Targeting Autophagy in Cancer

Session Chair(s)

• Rushika Perera

  Speaker
  University of California San Francisco

• Christina Towers

  Speaker
  Salk Institute

• Andrew Thorburn

  University of Colorado

This session will discuss recent advances in targeting autophagy as a treatment for cancer. Four leading investigators will discuss recent advances in the field that explain how autophagy modulation in cancer can affect anti-tumor immunity, how lysosomes regulate cancer behavior, the development of new autophagy inhibitors that target the lysosome in novel ways, and how cancer cell resistance to autophagy inhibitors can arise and may be circumvented.

Presentations:

• 11:00 AM – 11:05 AM

  Introduction
• 11:05 AM – 11:25 AM

  Role of Autophagy in Suppressing the Anti-cancer Immune Response
  

  Speaker: Eileen White – Rutgers University
• 11:25 AM – 11:45 AM

  New Features and Functions of Cancer Lysosomes
  

  Speaker: Rushika Perera – University of California San Francisco
• 11:45 AM – 12:05 PM

  Developing Autophagy Inhibitors for Cancer Clinical Trials
  

  Speaker: Ravi Amaravadi – Univ. of Pennsylvania
• 12:05 PM – 12:25 PM

  Mechanisms to Circumvent Autophagy Inhibition in Cancer Cells
  

  Speaker: Christina Towers – Salk Institute
• 12:25 PM – 12:30 PM

  Conclusion