Track: PHARMACOLOGY

Track: Cardiovascular

Track: Drug Discovery and Development

Track: Molecular Pharmacology

86 - Targeting Gq Signaling in Disease

Session Chair(s)

• Jeffrey Benovic

  Thomas Jefferson University

The heterotrimeric Gq protein family plays an important role in regulating signaling through a number of effectors. Gq signaling has been implicated in a number of diseases including asthma and uveal melanoma. Several inhibitors have been identified that can effectively and specifically inhibit Gq including constitutively active Gq mutants found in some cancers. The goal of this symposium is to provide: 1) insight into the development of Gq inhibitors that might be used to treat various diseases; 2) insight into the use of Gq inhibitors to treat disease; and 3) mechanistic insight into Gq inhibitor function.

Presentations:

• 8:00 AM – 8:03 AM

  Introduction
• 8:28 AM – 8:53 AM

  G Protein Inhibitors in Ocular Melanoma: Therapeutic Potential and Challenges
  

  Speaker: Kendall Blumer – Washington University
• 8:53 AM – 9:18 AM

  Mechanistic Insight into Gq Inhibitors
  

  Speaker: Philip Wedegaertner – Thomas Jefferson University
• 9:18 AM – 9:28 AM

  Identifying Novel Signaling Mechanisms Downstream of Gq-Coupled Receptors
  

  Presenting Author: Joseph Loomis – University of Michigan
• 9:28 AM – 9:30 AM

  Conclusion