364 - Ectopically Expressed Olfactory Receptors: Promises and Challenges of the Understudied GPCR Family

Session Chair(s)

• Vladlen Slepak

  Speaker
  University of Miami

• Jennifer Pluznick

  Speaker
  Johns Hopkins University School of Medicine

G protein-coupled receptors (GPCRs) are the arguably the most important drug target. About 50% of the ~800 GPCRs belong to the families of olfactory and taste receptors. While they were originally cloned from sensory organs, in the past decade expression of these genes was discovered in many other tissues. Technical difficulties with functional expression of these receptors in vitro and unavailability of tools for their analysis impeded progress in this field for many years. This session will highlight recent advances facilitating investigations of these understudied GPCRs and insights into their physiological functions, pharmacology and potential role in human disease.

Presentations:

• 8:00 AM – 8:05 AM

  Introduction
  

  Speaker: Vladlen Slepak – University of Miami
• 8:05 AM – 8:25 AM

  Emerging Roles for Olfactory Receptors in Glucose Homeostasis and Metabolism
  

  Speaker: Blythe Shepard – Georgetown University
• 8:25 AM – 8:40 AM

  Olfactory Receptor78 Participates in Carotid Body-Dependent Sympathetic Activation and Hypertension in Murine Models of Obstructive Sleep Apnea
  

  Presenting Author: Ying-Jie Peng – University of Chicago
• 8:40 AM – 8:50 AM

  The Role of Smell Receptors in the Kidney
  

  Speaker: Jennifer Pluznick – Johns Hopkins University School of Medicine
• 8:50 AM – 9:05 AM

  Uncovering a sex-specific role for olfactory receptor 558 (Olfr558) in blood pressure regulation
  

  Presenting Author: Jiaojiao Xu – Johns Hopkins University School of Medicine
• 9:05 AM – 9:25 AM

  Targeting Prostate Cancer Cells via Ectopically Expressed Olfactory Receptors OR51E1/2
  

  Speaker: Alexey Pronin – University of Miami School of Medicine
• 9:25 AM – 9:30 AM

  Conclusion