424 - G Protein Signaling in CNS Disorders

Session Chair(s)

• Qin Wang

  Speaker
  Medical College of Georgia

• Venetia Zachariou

  Speaker
  Icahn School of Medicine at Mount Sinai

This session will focus on recently identified roles of G protein signaling components in brain disorders, pointing to novel therapeutic pathways. Translational studies highlight the essential role of regulator of G protein signaling 4 in the maintenance of chronic pain states, the importance of spinophilin/coffilin interaction in post traumatic stress disorders, the impact of striatal cAMP signaling components on movement disorders and the impact of Gβγ–SNARE interaction on restoration of the release of hormones and neurotransmitters.

Presentations:

• 2:00 PM – 2:02 PM

  Introduction
• 2:02 PM – 2:20 PM

  Disabling Gβγ-SNARE Interaction Disrupts GPCR-mediated Presynaptic Inhibition Leading to Physiological and Behavioral Phenotypes
  

  Speaker: Heidi Hamm – Vanderbilt University
• 2:20 PM – 2:38 PM

  A Key Role of RGS4 in the Maintenance of Chronic Pain
  

  Speaker: Venetia Zachariou – Icahn School of Medicine at Mount Sinai
• 2:38 PM – 2:56 PM

  Activation of a Novel α2AAR-spinophilin-cofilin Axis Determines the Effect of α2 Adrenergic Drugs on Fear Memory Reconsolidation
  

  Speaker: Qin Wang – Medical College of Georgia
• 2:56 PM – 3:14 PM

  G protein Signaling in Motor Behavior
  

  Speaker: Brian Muntean – Augusta University, Medical College of Georgia
• 3:14 PM – 3:27 PM

  Development of Transgenic Mouse Models for the Expression of Optical Biosensors of Endogenous G Protein Activity
  

  Presenting Author: Remi Janicot – Boston University School of Medicine
• 3:27 PM – 3:30 PM

  Conclusion