110 - Transition from Acute to Chronic Critical Illness After Pneumonia: Long-Term Outcomes, End-Organ Dysfunction and Mechanisms

Session Chair(s)

• Brant Wagener

  Speaker
  University of Alabama at Birmingham

• Ji Young Lee

Mortality in critically ill patients has decreased due to improvements in hemodynamic support, mechanical ventilation strategies and bundled care. However, patients surviving to discharge have staggering rates of mortality, ~50%, during the next year of life. Furthermore, survivors have significant morbidity due to end-organ dysfunction. An NHBLI report suggests two erroneous paradigms that have limited our understanding of the role of pneumonia on health: that pneumonia is a 1) lt;emgt;localizedlt;/emgt; and 2) lt;emgt;acutelt;/emgt; disease. In fact, pneumonia causes end-organ injury by poorly understood mechanisms and the clinical manifestations persist long after resolution of the primary infection. Biological changes occurring during pneumonia that induce long-term morbidity are poorly understood. In summary, we propose to discuss exciting new mechanisms and hypotheses elucidating mechanisms of long-term morbidity and end-organ dysfunction in survivors of pneumonia that suffer from chronic critical illness.

Presentations:

• 8:30 AM – 9:00 AM

  Introduction and Clinical Aspects of Chronic Critical Illness After Pneumonia
  

  Speaker: Brant Wagener – University of Alabama at Birmingham
• 9:00 AM – 9:15 AM

  Dissecting breathing control dysregulation in neonatal sepsis
  

  Presenting Author: Michele Alves – The Ohio State University
• 9:15 AM – 9:30 AM

  Amyloid-Beta Precursor Protein: Essential to Lung Capillary Barrier Defense During Acute Infection
  

  Presenting Author: Sarah Voth – Edward Via College of Osteopathic Medicine - Louisiana
• 9:30 AM – 9:45 AM

  Influenza A Virus Causes Shedding of the Alveolar Epithelial Glycocalyx through Activation of Sheddases
  

  Presenting Author: Kaitlyn Schaaf – Vanderbilt University
• 9:45 AM – 10:00 AM

  Pulmonary Endothelial Tau Aggregation After Infection
  

  Presenting Author: Mike Lin – University of South Alabama