88 - COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

Session Chair(s)

• Kerry Goralski

  Dalhousie University

• Maria Croyle

  Speaker
  University of Texas at Austin

Acute infection and inflammation transiently suppress hepatic drug metabolism. This session will discuss clinical cases supporting altered pharmacokinetics of small molecules and biologics following SARS-CoV-2 infection or immunization and examine the mechanisms of interactions between the innate immune response and small molecule and biologic metabolism following SARS-CoV-2 infection or immunization. Understanding the impact of emerging infections and vaccine technologies on drug metabolism will help mitigate drug toxicity and improve drug and vaccine safety and effectiveness.

Presentations:

• 8:00 AM – 8:05 AM

  Introduction
• 8:05 AM – 8:30 AM

  A Case Report Exploring the Possibility of SARS-CoV-2 Vaccination Increasing Clozapine Levels
  

  Speaker: William Honer – University of British Columbia
• 8:30 AM – 8:55 AM

  Effect of COVID-19 Infection on the Innate Immune System and the Disposition of Complex Drugs
  

  Speaker: William Zamboni – University of North Carolina - UNC Eshelman School of Pharmacy
• 8:55 AM – 9:20 AM

  Impact of Emerging Infections and Vaccines on CYP450 Metabolism
  

  Speaker: Maria Croyle – University of Texas at Austin
• 9:20 AM – 9:30 AM

  Infection During Pregnancy Downregulates the Expression of Amino Acid Transporters in Rat and Human Placentas
  

  Presenting Author: Eliza McColl – University of Toronto