367.4 - Combating Evolutionary Drug Resistance by Targeting Heterogenous Cell-cell Interactions
Tuesday, April 5, 2022
9:00 AM – 9:25 AM
Room: 113 A - Pennsylvania Convention Center
Introduction: This session will explore how cancers evolve resistance to therapies. It will explore the importance of tumor heterogeneity, both genetic and epigenetic, and the microenvironment in the evolution of drug resistance. Attendees will also learn about the tradeoffs associated with drug resistance, and how these costs can be exploited for the design of more effective and less toxic therapeutic regimen. The application of evolutionary approaches to understand and to treat cancers will be demonstrated for multiple malignancies, including breast and prostate cancers and multiple myeloma.
