364.4 - Targeting Prostate Cancer Cells via Ectopically Expressed Olfactory Receptors OR51E1/2
Tuesday, April 5, 2022
9:05 AM – 9:25 AM
Room: 113 B - Pennsylvania Convention Center
Introduction: G protein-coupled receptors (GPCRs) are the arguably the most important drug target. About 50% of the ~800 GPCRs belong to the families of olfactory and taste receptors. While they were originally cloned from sensory organs, in the past decade expression of these genes was discovered in many other tissues. Technical difficulties with functional expression of these receptors in vitro and unavailability of tools for their analysis impeded progress in this field for many years. This session will highlight recent advances facilitating investigations of these understudied GPCRs and insights into their physiological functions, pharmacology and potential role in human disease.
Alexey Pronin ( University of Miami School of Medicine )
