110.1 - Introduction and Clinical Aspects of Chronic Critical Illness After Pneumonia
Sunday, April 3, 2022
8:30 AM – 9:00 AM
Room: 203 B - Pennsylvania Convention Center
Introduction: Mortality in critically ill patients has decreased due to improvements in hemodynamic support, mechanical ventilation strategies and bundled care. However, patients surviving to discharge have staggering rates of mortality, ~50%, during the next year of life. Furthermore, survivors have significant morbidity due to end-organ dysfunction. An NHBLI report suggests two erroneous paradigms that have limited our understanding of the role of pneumonia on health: that pneumonia is a 1) lt;emgt;localizedlt;/emgt; and 2) lt;emgt;acutelt;/emgt; disease. In fact, pneumonia causes end-organ injury by poorly understood mechanisms and the clinical manifestations persist long after resolution of the primary infection. Biological changes occurring during pneumonia that induce long-term morbidity are poorly understood. In summary, we propose to discuss exciting new mechanisms and hypotheses elucidating mechanisms of long-term morbidity and end-organ dysfunction in survivors of pneumonia that suffer from chronic critical illness.
Brant Wagener ( University of Alabama at Birmingham )
