The network of fasciae is an important part of the musculoskeletal system that is often overlooked. Fasciae are organized in layers, and fascia mobility, especially along shear planes separating muscles, is critical for musculoskeletal function. Patients with connective tissue hyper- and hypo-mobility disorders suffer in large numbers from musculoskeletal pain. The relationship between fascia mobility and myofascial pain is largely unstudied, but a better understanding of this area could result in improved care for many patients with musculoskeletal pain.