Regulation of mRNA stability and translation is increasingly recognized as a critical control point in dynamically altering gene expression during stress or disease. In the heart, post-transcriptional alteration of the level of select mRNAs has emerged as a driver of disease. Cardiac inflammation, hypertrophy, metabolism and electrophysiology are all aspects that are perturbed in pathophysiologic conditions and undergo regulation by RNA-binding proteins. My talk will focus on novel molecular mechanisms responsible for controlling cardiac mRNA fate in heart disease.
