(953.6) BPA and BPS increase oxidative stress inducing a decrease in physical fitness and dyslipidemia in young adults

Poster Board Number: E554

Julia Santos (Fairmont State University), Jessica Jones (West Virginia University), Tyler Sine (Fairmont State University), Daniela Senador (Wayne State University), Amanda Metcalf (Fairmont State University), Andrea Haney (Fairmont State University)

Objectives – Bisphenol-A and -S (BPA and BPS, respectively) exposure occurs primarily due to leaching of these chemicals from the packaging of industrialized food. BPA and BPS intake is indicative of unhealthy lifestyle choices. Levels of BPA and BPS in human specimens have been closely associated with dyslipidemia and insulin resistance. Physical exercise has been shown to attenuate insulin resistance and the development of type 2 diabetes (T2D). The aim of this study was to investigate the relationship between lipid profiles, levels of BPA, BPS, oxidative stress, and their influence on glucose uptake induced by insulin and aerobic exercise. 

Methods – Healthy young adults (age 23.5±2 years old) participated in 2 separate testing days. In both days, subject’s blood glucose (BG) was measured before 50g of maltodextrin consumption and following 30-, 60-, and 75-minutes. On the “Exercise” testing day, subjects ran for 30-minutes, while on the “Rest” day, they remained seated. Urinary BPA, BPS, and oxidative stress (OS), lipid profile, as well as body fat were also assessed. Distance ran was used to assess physical fitness.

Results – The exercise condition produced a decrease in BG during the 30-60-minute protocol interval when compared to the resting day. The decrease of BG in the resting and exercise days were correlated with body fat (r=0.5 and 0.51, respectively). Levels of BPA and OS were negatively associated with decreased physical fitness (r=-0.45 and -0.5, respectively), while BPS and OS were associated with increased triglycerides (TG) levels (r=0.5 for both). Levels of OS were positively associated with levels of BPA and BPS (r=0.62 and 0.82), respectively.

Discussion – Concentration of BPA and BPS in urine may not directly affect glucose transport in healthy young adults. BPA and BPS might induce increase in OS and further TG affecting physical fitness and potentially mediating changes linked to the development of T2D.

Support or Funding Information

NASA West Virginia Space Grant Consortium, Training Grant #80NSSC20M0055, Fairmont State Foundation, Inc.