(803.1) Find out if your protein is O-GlcNAc modified: The O-GlcNAc database
Tuesday, April 5, 2022
12:30 PM – 1:45 PM
Location: Exhibit/Poster Hall A-B - Pennsylvania Convention Center
Poster Board Number: A232
Stephanie Olivier-Van Stichelen (Medical College of Wisconsin), Florian Malard (Medical College of Wisconsin), Rex Berendt (Medical College of Wisconsin), Eugenia Wulff-Fuentes (Medical College of Wisconsin), Laura Danner (Medical College of Wisconsin)
Presenting Author Medical College of Wisconsin Milwaukee, Wisconsin
Post-translational modifications (PTMs) are ubiquitous and essential for protein function and signaling, motivating the need for sustainable benefit and open models of web databases. Highly conserved O-GlcNAcylation is a case example of one of the most recently discovered PTMs, investigated by a growing community. Historically, details about O-GlcNAcylated proteins and sites were dispersed across literature and in non-O-GlcNAc-focused, rapidly outdated or now defunct web databases. In a first effort to fill the gap, we recently published a human O-GlcNAcome catalog with a basic web interface. Based on the enthusiasm generated by this first resource, we extended our O-GlcNAcome catalog to include data from 42 distinct organisms and released the O-GlcNAc Database v1.2. In this version, more than 14 500 O-GlcNAcylated proteins and 11 000 O-GlcNAcylation sites are referenced from the curation of 2200 publications. Here, we present the extensive features of the O-GlcNAc Database, including the user-friendly interface, back-end and client–server interactions. Finally, this database system can be administrated with little to no programming skills and is meant to be an example of a useful, sustainable and cost-efficient resource, which exclusively relies on free open-source software elements (www.oglcnac.mcw.edu).
