In the United States, there is an increasing number of teenagers and young adults, including women of childbearing age, who vape. With more than 10% of women admitting using electronic-cigarettes (e-cigs) during their pregnancy, there is a pressing need to investigate the effects of in utero e-cig aerosol exposures on the developing lungs. As shown with active smoking during pregnancy, nicotine can alter prenatal development. Since e-cigs are nicotine delivery devices, we used mouse models of in utero exposures to further our understanding of how flavored e-cig aerosols affect the developing lungs, both at birth and later in life.