(526.7) Prospects of transient elastography’ using in the veterinary hepatology

Poster Board Number: D24
Introduction:

Vladimir Ponomarev (St. Petersburg State University of Veterinary Medicine), Nadezhda Andreeva (St. Petersburg State University of Veterinary Medicine), Oksana Popova (St. Petersburg State University of Veterinary Medicine)

Elastography is the qualitative and quantitative analysis of tissue’ elastic characteristics. The diagnostic of hepatopathies is based on the puncture biopsy of the liver. At the same point,  the low biochemical activity of liver diseases is not always associated with the analogic histologic pattern. There were not excluded the advance of hepatic pathology. The primary hypothesis of this research was the prospects of transient elastography used in the diagnosis of hepatic disorder in animals. The methodology is about the formation of rotational waves in the determinate organ and measuring their velocity. The rotational wave has generated by a special detector which has the source of mechanical vibrations. The detector is located on the patient’s body surface in the zona of the organ’s projection. The studies were carried out in the laboratory animals, which were rabbits (n=20). The tool was used iLIvTouch. Standard methods also performed the liver biopsy and histological examination. Thus, we have detected the correlation between parameters of liver stiffness and the biopsy’ results performing transient elastography. The histology was pointing to the specific diagnosis: the fatty hepatosis with liver stiffness in 3.8-4.2 kPa (n=10, the normal range was 5.8 kPa). Liver fibrosis was also diagnosed with liver stiffness in 6.2-6.8  kPa (n=5) and toxic hepatitis with liver stiffness in 3.2-3.6  kPa (n=5). The results of our research on laboratory animals after hepatopathies’ induction with different pathogenesis showed that the parameters of liver stiffness using transient elastography correlated with the results of the morphological evaluation. So, we can assume prospects of transient elastography using equally with standard methods.