Presenting Author Hamilton High School Chandler, Arizona
Objectives: Metformin is an FDA-approved anti-diabetic drug. The oral bioavailability of metformin is low. After oral intake of metformin at 0.5-3 g/day, blood metformin levels are less than 40 μM in human subjects. We successfully synthesized biocompatible and biodegradable metformin nanoliposomes. The objectives of this study are to measure the characteristics of metformin nanoliposomes and to determine their stability at three different temperatures.
Methods: The particle size and polydispersity index of metformin nanoliposomes were measured using a dynamic light scattering technique, and their surface charges were measured using a zeta potential analyzer. The metformin nanoliposomes were stored at 4°C, 22°C and 37°C for 5 days, and their stability was measured every day.
Results: The mean particle size of metformin nanoliposomes was around 100 nm. The polydispersity index value was less than 0.3. Moreover, the zeta potential of metformin nanoliposomes was around −20 mV. The particle size, polydispersity index and zeta potential of metformin nanoliposomes were stable at 4°C for 24 hours, but were increased at 22°C and 37°C after 24 hours.
Conclusions: Metformin can be encapsulated into biocompatible and biodegradable nanoliposomes. They are stable at 4°C for 24 hours.
