(516.13) Antioxidant Effects of Guishe Extract from Agave lechuguilla on Kidney Mitochondria from Stz-Induced Diabetic Male Rats

Poster Board Number: A415

Edgar Esquivel-Gutiérrez (Centro de Investigaciones Biológicas del Noroeste S.C.), Donovan Peña-Montes (Universidad Michoacana de San Nicolás de Hidalgo), Alfredo Saavedra-Molina (Universidad Michoacana de San Nicolás de Hidalgo), Ana Reyes (Centro de Investigaciones Biológicas del Noroeste S.C.)

Guishe from Agave lechuguilla was used to test the capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a crude aqueous extract from lyophilized guishe was administered over 5 weeks at different doses (150, 300 y 600 mg/kg). Blood glucose and body weight were monitored. The activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione and glutathione peroxidase were determined in isolated kidney mitochondria. Our results show that guishe extracts regulates the oxidative stress observed in isolated kidney mitochondria. In conclusion, we found that guishe at doses of 300 mg/kg of body weight has a beneficial effect as an antioxidant and can be used to mitigate the oxidative stress occurring during diabetes. 

Support or Funding Information

This research and the APC were supported by the National Council of Research and Technology of Mexico (CONACyT) through the project to deal with National Problems (PN-2017-73332).