Rei Unno, MD

As a lead investigator in our department at Nagoya City University Graduate School of Medical Sciences, I have been dedicating my time to kidney stone research both for clinical and basic points of view. My research goal is not only to find reliable, better treatment of the disease, but also elucidating its pathogenesis for the better understand of the ultimate cure of the disease. In order to achieve this goal, our lab established a kidney stone mouse model so that we have been able to conduct pathophysiological investigations using transgenic mice for unveiling the mechanism of kidney stone formation. While establishing pathophysiological analyses using this mouse model, I investigated that the influence of obese via inflammation and oxidative stress on stone disease using both in vitro and in vivo experiments, which resulted in finding collaboration of both decrease of autophagy and adipocytes for facilitating kidney stone development. Beyond basic over translational researches, we have also conducted and summarized genome-wide analyses of human renal tissue and in vitro/vivo studies of renal macrophage and autophagy to develop molecular target/crystal dissolution therapy for kidney stone disease.
In addition to these basic research work, my clinical interest has been finding a better care for patients with stone disease in medical and surgical fashion.

Disclosure information not submitted.

Presentation(s):

• MP02-20: Decreased risk of urinary infection is associated with single use ureteroscopes

  Friday, May 13, 2022
  7:00 AM – 8:15 AM