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Clinical and Translational Nutrition
Cellular and Physiological Nutrition/Metabolism
.jpg "Joshua Miller, PhD (he/him/his) photo")
Joshua Miller, PhD (he/him/his)
Professor & Chair of Nutritional Sciences
Department of Nutritional Sciences, Rutgers University
New Brunswick, New Jersey, United States
Disclosure(s): Church & Dwight Co.: Consultant (Terminated); Independent Contractor (including contracted research) (Terminated)
Jim Ray, PhD
Executive Director
Neuroscience
The Neurodegeneration Consortium MD Anderson Cancer Center
Houston, Texas, United States
Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.
Vilhelm Bohr, MD, PhD
Laboratory Chief
Laboratory of Molecular Gerontology
National Institutes on Aging, National Institutes of Health
Baltimore, Maryland, United States
Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.
Charalampos Tzoulis, MD, PhD
Haukeland University Hospital, University of Bergen, Norway
Disclosure information not submitted.
Age-related cognitive decline and neurodegenerative diseases can be exacerbated by exposure to various metabolic stresses over time, such as oxidative stress and inflammation. Nutritional interventions may be able to counter these effects and slow or delay functional decline. Preclinical models exist to assess the effect of various bioactive dietary components on cognitive decline. These models have been utilized to demonstrate the critical role of nutritional components such as the coenzyme nicotinamide adenine dinucleotide (NAD) and the essential nutrient choline in the normal function of neural tissue. Studies in preclinical models have demonstrated that interventions with nutrients such as nicotinamide riboside (NR) and choline can lead to beneficial changes in the brain and nervous system, including increasing NAD concentrations and altering epigenetic modifications in the brain. This research has in turn informed the design and execution of pilot human clinical trials aimed at investigating the effect of these nutrients on neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, with several additional trials underway. These studies suggest that supplementation with nutrients such as NR or Choline may be effective interventions to slow or delay functional declines that are characteristic of neurodegenerative disease.
Chair: Joshua W. Miller, PhD (he/him/his) – Department of Nutritional Sciences, Rutgers University
Speaker: Jim Ray, PhD – The Neurodegeneration Consortium MD Anderson Cancer Center
Speaker: Vilhelm Bohr, MD, PhD – National Institutes on Aging, National Institutes of Health
Speaker: Charalampos Tzoulis, MD, PhD – Haukeland University Hospital, University of Bergen, Norway
Speaker: Jim Ray, PhD – The Neurodegeneration Consortium MD Anderson Cancer Center
Speaker: Vilhelm Bohr, MD, PhD – National Institutes on Aging, National Institutes of Health
Speaker: Charalampos Tzoulis, MD, PhD – Haukeland University Hospital, University of Bergen, Norway
Chair: Joshua W. Miller, PhD (he/him/his) – Department of Nutritional Sciences, Rutgers University