Background: Home infusion of Parenteral Nutrition (HPN) is increasingly prevalent in patients with chronic intestinal failure. They are trained to self-infuse at home, using smart infusion pumps enabling independence, while maintaining an optimal nutritional status (1). HPN is improving quality of life and nutritional outcomes in many clinical conditions and can increase weight in cancer patients (2,3,4). With clinical resources often remote, patients are at risk of non-compliance. Follow ups for HPN infusion treatment plans can be infrequent with assessments of effectiveness based on lab results and subjective patient reports. Objective delivery data from Infusion Pump reports have the potential to support lab results and subjective patient reports both remotely and at follow ups, supporting treatment progress monitoring and medication planning. .
Purpose: The aim of this study was to demonstrate the efficacy and accuracy of Insights digital health platform for home TPN use. We hypothesize that the data recorded by patients is reflected in the data recorded in the platform.
Methods: 20 HPN patients with a minimum of 3 weekly infusions using the Sapphire Infusion Pump for at least 2 months were recruited over a year in 2022 (IRB approved). Weighing scales and manual forms were supplied to patients to record 3 infusions: the pre and post infusion HPN bag weight, the duration of infusion and the alarms. The weight of the administration set, and residual volume remaining was removed from the manually recorded bag weight, converted to mL, deducted from the pre-infusion bag weight, and compared to the volume infused as recorded by the pump and Eitan Insights platform (a digital platform providing data driven insights from the pump recorded data). Manually recorded treatment duration were compared to the pump data, assessing the correlation between the data points for each patient’s HPN infusions. Repeated Measures ANOVA procedure was used for statistical analysis.
Results: Attrition rate of 5/20, 45 data sets collected. No adverse events were noted during the study. Multiple comparisons for in-between subject factors and descriptive statistics found that there was no significant difference between manual vs pump recorded data sets for Volume infused (Values of manual versus pump in mean 1707mL +/- 362mL and 1708mL +/- 405 P Value= 0.939) and infusion duration (Values of manual versus pump in mean 9:43 +/- 2.48 SD VS 9:45 +/- 2.41 SD P Value= 0.858). NA
Discussion: The data collected by the digital platform accurately reflects the patient’s infusion data supporting the study’s hypothesis. Future research would assess the impact of treatment data, as presented on insights platform, on treatment outcomes. NA
Conclusions: The study showed data was accurately captured by the pump, providing insights on the digital health platform. These insights could be useful in studying correlations between treatment data and clinical outcomes as well as providing potential for cost savings in parenteral nutrition purchasing. Home-based therapies could benefit from remote treatment data visibility. This connected device has the potential to allow clinicians to be more informed, assess treatment trends and proactive resource planning through the infusion pump data insights. NA