(278) Reference values of the ductus venosus pulsatility index for Colombian pregnant women

Objective: Ductus venosus pulsatility index velocity (DV PIV) is a standard ultrasonographic measurement in the first trimester of pregnancy. Currently, its reference value has not been established in the Latino population. Therefore, our goal was to determine a reference value for the DV PIV.

Study Design: We conducted a retrospective study of our 11 to 14 weeks screening ultrasound records from 2018 to 2021. Our inclusion criteria were as follows: singleton pregnancy; craniocaudal length (CRL) between 45 and 84 mm; absence of structural abnormalities on ultrasound examination; and absence of chromosomal abnormalities on neonatal examination.
All ultrasound exams are performed based on a standard of care protocol for 11-14 weeks of screening ultrasound defined by the Fetal Medicine Foundation with a Voluson E8 and E10 ultrasound machine (5-8 MHz 3D transducer; General Electric Healthcare, Little Chalfont, UK). A descriptive analysis was performed according to the nature of each variable using SPSS 28 software (IBM, Armonk, NY).

Results: 948 patients were included, of which 529 met the inclusion criteria, the average maternal age, body mass index and gestational age was 33 (±) 4 years, 23 .6 (±) 2.4 and 13.1 (±) 0.4 weeks, respectively. 53% (280) of the patients were nulliparous. DV PIV measurements with a Gaussian distribution were adequate according to the Shapiro-Wilk test (p: 261). The mean DV PIV is 1.05, 95% CI (0.99 – 1.11). The 5th and 95th percentiles were 0.69 and 1.27, respectively. Showing that values below 0.69 and above 1.27 were outside the normal range.

Conclusion: We defined cut-off points for DV PIV in this cohort of pregnant women. Thus determining their normal ranges to anticipate maternal-perinatal pathologies and adverse perinatal events.