Category: Diabetes
Poster Session I
Evidence suggests that the consequences of macrosomia on offspring’s health echoes well beyond the neonatal period. In this study we have delineated the potential association between diabetes mellitus during pregnancy - a major risk factor for macrosomia, and offspring’s neurological morbidity.
Study Design:
A population-based cohort study was conducted, that included consecutive deliveries of macrosomic infants (birthweight above 4 kilograms) occurring between the years 1991 to 2021 at a tertiary referral hospital. Neurological outcomes of offspring of both diabetic and non-diabetic mothers were compared. A Kaplan-Meier survival curve compared cumulative morbidity. A Cox proportional hazards model was used to control for confounders.
Results:
A total of 16,466 infants diagnosed with macrosomia were included in the analyses, 11.1% of them were of diabetic mothers (pregestational and gestational diabetes mellitus). Total neurological-related hospitalizations were higher in offspring of diabetic mothers (OR=1.31, 95% CI 1.09-1.57, P< 0.05; Table). Likewise, higher cumulative incidence of hospitalizations was observed among the exposed group using a Kaplan-Meyer survival curve (log rank p-value=0.018; Figure). The association between exposure to diabetes mellitus and neurological morbidity remained significant in the Cox proportional hazards model (adjusted HR = 1.20, 95% CI 1.01–1.44, p=0.044), controlling for maternal age, preterm delivery and hypertensive disorders complicating pregnancy.
Conclusion: Macrosomic infants of diabetic mothers are faced with higher rates of neurological morbidity as compared to their non-diabetic macrosomic counterparts.
Omri Zamstein, MD
Soroka University Medical Center
Beer Sheva, Israel
Tamar Wainstock, PhD (she/her/hers)
Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev
Beer Sheva, HaDarom, Israel, Israel
Eyal Sheiner, MD,PhD
Head of department of Obstetrics and Gynecology B, Soroka University Medical Center
Soroka Medical Center
Omer, HaDarom, Israel