Category: Hypertension
Poster Session II
This is a cohort study of births in California (2000-2012) that included two consecutive singleton deliveries with gestational age 23-42 weeks, excluding pregnancies with pre-existing diabetes or major chromosomal anomalies. We compared the prevalence of CHD in the subsequent pregnancy to preeclampsia in the index pregnancy. We used multivariable logistic regression to examine the association of preeclampsia in the index pregnancy with fetal CHD and delivery timing in the subsequent pregnancy controlling for sociodemographic factors.
Results:
Among 926,684 pregnant patients, 3.98% had preeclampsia in the index pregnancy. Those preeclamptic patients had a significantly increased incidence of having offspring with CHD in the subsequent pregnancy, compared to those without preeclampsia (0.79% vs 0.53 %, p < 0.001). After adjusting for confounders, there was an increased risk of fetal CHD in subsequent pregnancy among patients with preeclampsia in index pregnancy (aOR 1.47, 95% CI 1.31-1.66). When stratified by age, this risk was significant in subgroups for individuals >20 years old. Among patients who had a baby with CHD in the subsequent pregnancy, the risk of an early delivery was higher for those who had preeclampsia in the index pregnancy (aOR 1.52, 95% CI 1.18-1.96).
Conclusion:
For those with preeclampsia in the index pregnancy, there is an increased risk of CHD in the offspring in the subsequent pregnancy, and amongst patients with CHD in the subsequent pregnancy, the odds of preterm delivery are higher in pregnant patients with preeclampsia in the index pregnancy. Stratifying by age remained significant in subgroups >20 years old. This interrelationship of pregnant patient and offspring disease across pregnancies should be further evaluated.
Isabel Katlaps, BS (she/her/hers)
Oregon Health and Science University
Portland, Oregon, United States
Bharti Garg, MBBS, MPH
Biostatistician/Data analyst
Department of Obstetrics and Gynecology, Oregon Health and Science University
Portland, Oregon, United States
Afsoon Ghafari-Saravi
Medical Student
Oregon Health and Science University
Portland, Oregon, United States
Sarina R. Chaiken, BA (she/her/hers)
Medical Student
Oregon Health and Science University
Portland, Oregon, United States
Ava Mandelbaum, BA (she/her/hers)
Oregon Health and Science University
Portland, Oregon, United States
Christina Ronai, MD, MEd
Boston Children's Hospital
Boston, Massachusetts, United States
Aaron B. Caughey, MD,MPH,PhD
Professor and Chair
Oregon Health and Science University
Portland, Oregon, United States
Erin Madriago, MD
Oregon Health and Science University
Portland, Oregon, United States