Category: Infectious Diseases
Poster Session III
COVID-19 during pregnancy has been shown to be associated with higher risk of significant maternal morbidity as well as pregnancy complications including preterm labor and low birthweight. However, data regarding COVID-19 reinfection in pregnant women is lacking. We aim to describe and evaluate clinical manifestations and maternal and perinatal outcomes in pregnant women with COVID-19 re-infection.
Study Design:
We conducted a national, population-based, historical cohort study of all pregnant women who delivered in Israel between December, 2021 and July, 2022. We assessed and compared maternal and neonatal outcomes in pregnant patients who had their first bout of COVID-19 vs. re-infection during pregnancy. Disease cases were collected from the period that the Omicron variant was dominant (December 15, 2021 to February 15, 2022); pregnancies were followed to the end of the study period: 17 July, 2022. Comparison between first COVID-19 infection vs. re-infection was performed using Chi square or Fisher's exact test or Student t-test, as appropriate.
Results:
A total of 4,297 pregnant patients were followed during the study period: 2,784 underwent first COVID-19 infection, and 1,513 experienced re-infection. The incidence of COVID-19-related hospitalizations was significantly lower in the re-infected COVID-19 group (5.0% vs. 10.4%, p< 0.001, OR=2.22). Stratified by COVID-19 disease severity, the data showed a significantly lower rate of maternal significant disease during hospitalization among the re-infection group (0.1% vs. 0.7%, p=0.011), but the groups did not differ in rate of severe disease during hospitalization (p=0.110). The rate of p</span>reterm deliveries did not differ between groups (p=0.539), and nor did the rates of low or very low birthweight.
Conclusion:
This national cohort data provide the first evidence regarding the impact of COVID-19 re-infection during pregnancy. Reinfection was associated with significantly lower rates of COVID-19 related morbidity, while the rates of preterm birth and low or very low birthweight did not differ between groups suffering first or subsequent infections.
Adva Cahen Peretz, MD, MPH
Hadassah Mount Scopus Medical Center
Jerusalem, Yerushalayim, Israel
Michal Lipschuetz, MD
Hadassah University Medical Center, Mt. Scopus, Jerusalem
Jerusalem, Yerushalayim, Israel
Joshua Guedalia, MBA
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Jerusalem, Yerushalayim, Israel
Ronit Calderon-Margalit, PhD
The Hebrew university, Jerusalem
Jerusalem, Yerushalayim, Israel
Sarah Cohen, MPH
Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Mount-Scopus
Jerusalem, Israel, Israel
Asnat Walfisch, MD
Hadassah Mount Scopus
Jerusalem, Yerushalayim, Israel
Simcha Yagel, MD
Hadassah-Hebrew University Medical Center
Jerusalem, Israel, Israel
Ofer Beharier, MD, PhD
Hadassah Mount Scopius Hospital, The Hebrew University
Jerusalem, Yerushalayim, Israel