(739) The Effect of Multiple Doses of Misoprostol for Missed Abortion Treatment on Subsequent Pregnancy Outcome

1,110 women were included in our study: 771 (69.46%) in group 1 and 339 (30.54%) in group 2. As shown in Table 1, in group 2 there more multiparous women (37.61% vs. 28.61%, p=0.011), with a higher rate of previous surgical hysteroscopy for RPOC. Women who received multiple doses of Misoprostol were more likely to have labor induction or augmentation in the subsequent pregnancy (p < 0.001), although the mode of delivery was similar between the groups (Table 2). As shown in Table 2, women of group 2 had a higher risk for immediate RPOC (9.43% vs. 4.8%, p=0.008), postpartum hemorrhage (PPH) (5.31% vs. 2.46%, p=0.043), and blood transfusion (2.36% vs. 0.91%, p=0.048).

Conclusion: Multiple doses of Misoprostol used in women with MA, is associated with a higher rate of adverse maternal outcome, including RPOC in the subsequent delivery. Our findings should be used for consulting and managing these patients.