(776) Neonatal morbidity and mortality associated with gestational weight gain in women with polycystic ovarian syndrome

This was a retrospective cohort analysis of pregnancies among women with a history of PCOS between 2007 and 2012. Data was abstracted from the California Office of Statewide Health Planning and Development (OSHPD) Linked Birth File with hospital discharge International Classification of Diseases, 9^th Revision, Clinical Modification (ICD-9-CM) diagnoses. Pregnancies in women with a history of PCOS were stratified based on the Institute of Medicine 2009 recommendations for gestational weight gain (GWG) as follows: adequate weight gain, excessive weight gain, inadequate weight gain, or weight loss. Primary outcome of interest was neonatal death. Secondary neonatal outcomes collected were 5-minute Apgar score ≤3, large for gestational age infant, small for gestational age infant, and neonatal intensive care unit admission. Logistic regression analysis was performed to estimate the odd ratio of the outcomes of interest for each GWG stratum, with adjustments for confounding variables.

Results: There were 3,161,821 pregnancies, with 4,233 women with history of PCOS. There were no statistically significant differences between neonatal death in women with history of PCOS compared to women without PCOS. In addition, there were no significant differences in outcomes between the two groups for 5-minute Apgar score ≤ 3, large for gestational age infants, small for gestational age infants, and neonatal intensive care unit admission.

Conclusion: Gestational weight gain in pregnancies affected by PCOS have no higher risks of neonatal mortality or morbidity compared to women without PCOS.