(866) Cardiovascular diseases among macrosomic infants of diabetic mothers

A population-based cohort analysis including deliveries of macrosomic infants (birthweight above 4 kilograms) between the years 1991 to 2021 at a tertiary referral hospital was conducted. Incidence of hospitalizations due to various cardiovascular conditions was compared between infants of women with and without diabetes. A Kaplan-Meyer survival curve was used to assess cumulative hospitalization incidence. A Cox proportional hazards model was used to control for confounders.

Results: Of the 16,466 macrosomic infants, 11% were of women with diabetes during pregnancy (pregestational and gestational diabetes mellitus). Offspring of both diabetic and nondiabetic mothers had comparable rates of cardiovascular-related hospitalization during childhood and adolescence (1.5% and 1.1% respectively, p=0.155; Table). Cumulative incidence of hospitalizations was similar, as shown in the Kaplan-Meyer survival curve (log rank p-value=0.246; Figure), and A Cox proportional hazards model found no association as well (adjusted HR = 1.27, 95% CI 0.82–1.95, p=0.284).

Conclusion: In our population of macrosomic infants, diabetes mellitus does not seem to be associated with elevated rates of cardiovascular diseases.