(913) Perinatal outcomes among pregnant patients with peripartum COVID19 infection

During the study period, there were 30,712 singleton deliveries at our center. 564 (1.8%) of them had peripartum COVID19. Peripartum COVID19 was associated with preterm deliveries both near-term (34-36 weeks) and remote from term (below 34 weeks) with an adjusted OR of 1.6 and 2.1, respectively (p= 0.007 and 0.004). Patients with COVID19 had a higher incidence of urgent cesarean deliveries (CD) in comparison to non-COVID19 patients, with 75.5% and 56.1%, respectively (p < 0.001). Although not statistically significant, among patients with COVID19 infection, the leading indication for CD was Non-Reassuring Fetal Heart Rate (NRFHR) in 29.6% of CDs and in the non-COVID19 group the main indication was previous multiple CDs in 23.2% of CDs. Also, there were significantly higher rates of DIC (adjusted OR of 21.15, p < 0.001). As for hypertensive disorders of pregnancy, though demonstrated higher rates in the COVID19 group (OR 1.5, p=0.021), that association didn’t reach statistical significance after adjustment for potential confounders.
There was an association between COVID19 and neonatal lower Apgar scores and birthweights, however, that association was not demonstrated after adjustment for parity and gestational age.

Conclusion:

Peripartum COVID19 is associated with preterm deliveries, urgent CD and DIC. This might be in concordance with the pathophysiology of the infection and its association with coagulation changes.