Category: Physiology/Endocrinology
Poster Session IV
We identified 237 genes related to heart and placental development that are also modulated in PGDM. These genes were largely found in the placental endothelium and mesenchyme, as well as the endocardium, cardiac mesenchyme, and early cardiomyocyte progenitors. These DEGs are involved in neurodevelopmental processes, angiogenic signaling, adhesive/hemostatic functions, and mesenchyme formation. Of these genes, 58 have been previously identified in human cardiac CHD tissue, and 48 have been identified in placentas from CHD pregnancies.
Conclusion: A host of neuropathic, angiogenic, and mesenchymal factors involved in placentation, CHD, and diabetes remain unidentified in targeted transcriptomic evaluations. These processes may be key to future investigation of CHD in PGDM and must be studied further to determine their role in the perturbation of the Placenta-Heart axis.
Aditya D. Mahadevan, BS (he/him/his)
MD/PhD Candidate
University of Florida College of Medicine
Gainesville, Florida, United States
Helen Jones, BSc, PhD
Head of Research, Assistant Professor
University of Florida
Gainesville, Florida, United States