Category: Epidemiology
Poster Session II
There are limited data on the recurrence risk of placental abruption in successive pregnancies. Therefore, we assessed the rate and recurrence risk of placental abruption in subsequent pregnancies and whether interpregnancy intervals modify this association.
Study Design:
We conducted a retrospective cohort study of the 1st two (n=93,444) consecutive singleton pregnancies using the 1998-2020 Kaiser Permanente Southern California longitudinally-linked health records. ICD-9 and ICD-10 codes “641.20 and O45.x” identified placental abruption. The adjusted relative risks (RR) of placental abruption recurrence with their 95% confidence intervals were quantified.
Results:
The rate of placental abruption in the second pregnancy among women with and without previous placental abruption were 3.51% and 0.60%, respectively (adjusted RR=5.54, 95% CI: 3.51-8.73). We observed a significantly increased risk of recurrence in subsequent pregnancies regardless of the interval between pregnancies (table).
Pregnancy Intervals | 1st Pregnancy | Rate and Risk of Placental Abruption in the 2nd Birth | |
Abruption (%) | Adjusted RR (95% CI) | ||
0-11 months | No Abruption | 0.64 | 1.0 (reference) |
| Abruption | 3.33 | 4.91 (1.74, 13.8) |
12-23 months | No Abruption | 0.56 | 1.0 (reference) |
| Abruption | 4.40 | 7.75 (3.75, 16.04) |
≥24 months | No Abruption | 0.62 | 1.0 (reference) |
| Abruption | 2.99 | 4.54 (2.21, 9.29) |
These results suggest that prior placental abruption predicts an increased risk for a subsequent placental abruption regardless of the interval between pregnancies. These findings may have implications for patient counseling as well as for directions for future research pursuits.
Yinka Oyelese, MD (he/him/his)
Director, Obstetric Imaging
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Yinka Oyelese, MD (he/him/his)
Director, Obstetric Imaging
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Morgan Peltier, PhD
NYU-Long Island School of Medicine
Mineola, New York, United States
Nehaa Khadka, MPH
Department of Research and Evaluation, Kaiser Permanente Southern California
Pasadena, California, United States
Vicki Y. Chiu, MSc
Programer/Analyst
Department of Research and Evaluation, Kaiser Permanente Southern California
Pasadena, California, United States
Michael J. Fassett, MD
Department of Obstetrics-Gynecology, Kaiser Permanente West Los Angeles Medical Center
Los Angeles, California, United States
Darios Getahun, MD, PhD, MPH
Research Investigator MD II
Department of Research and Evaluation, Kaiser Permanente Southern California
Pasadena, California, United States